Liu Bailiang, Jin Luyuan, Nan Boyuan, Sun Zhongyi, Chen Fengyang, Zhou Yinghui, Sa Qila, Feng Yingnan, Men Ao, Wang Wenxin, Feng Xiaodong, Zhang Wei
Department of Hepatobiliary Surgery, General Hospital of Northern Theater Command, Shenyang, China.
Postgraduate College, Dalian Medical University, Dalian, China.
Front Nutr. 2024 Dec 20;11:1506477. doi: 10.3389/fnut.2024.1506477. eCollection 2024.
Previous studies have shown that inflammation is crucial in gallstone formation. The Advanced Lung Cancer Inflammation Index (ALI) is a comprehensive measure that reflects inflammation and nutritional condition. However, there are no studies examining the relationship between ALI and gallstones. This study aimed to analyze this association in US adults.
This study used a cross-sectional research design with in-depth analyses using data from the National Health and Nutrition Examination Survey (NHANES). The association between gallstones and ALI was systematically assessed by logistic regression analysis, subgroup analysis, basic participant characteristics, and smooth curve fits.
5,646 people participated in the study. ALI was converted into Quartile 1 (-1.47-1.00), Quartile 2 (1.00-1.34), Quartile 3 (1.34-1.69), and Quartile 4 (1.69-4.38). In the fully adjusted model, gallstone prevalence increased by 45% in participants in the highest quartile compared to those in the lowest quartile (OR = 1.45; 95% CI: 1.12-1.87; = 0.005), and ALI was positively correlated with gallstones (OR = 1.22; 95% CI: 1.03-1.45; = 0.0232). Smooth curve fits provided evidence in favor of this finding. Significant gender differences were found in the relationship between gallstones and ALI by subgroup analysis (OR = 1.43; 95% CI: 1.16-1.76; for interaction = 0.0204).
The study concluded that ALI and gallstones had a positive correlation, with ALI having a higher effect on women's gallstone prevalence.
先前的研究表明，炎症在胆结石形成过程中至关重要。晚期肺癌炎症指数（ALI）是一种反映炎症和营养状况的综合指标。然而，尚无研究探讨ALI与胆结石之间的关系。本研究旨在分析美国成年人中二者的关联。
本研究采用横断面研究设计，并利用国家健康与营养检查调查（NHANES）的数据进行深入分析。通过逻辑回归分析、亚组分析、基本参与者特征分析和平滑曲线拟合，系统评估胆结石与ALI之间的关联。
5646人参与了本研究。ALI被转换为四分位数1（-1.47 - 1.00）、四分位数2（1.00 - 1.34）、四分位数3（1.34 - 1.69）和四分位数4（1.69 - 4.38）。在完全调整模型中，与最低四分位数的参与者相比，最高四分位数的参与者胆结石患病率增加了45%（比值比[OR] = 1.45；95%置信区间[CI]：1.12 - 1.87；P = 0.005），且ALI与胆结石呈正相关（OR = 1.22；95% CI：1.03 - 1.45；P = 0.0232）。平滑曲线拟合为这一发现提供了证据。亚组分析发现，胆结石与ALI之间的关系存在显著性别差异（OR = 1.43；95% CI：1.16 - 1.76；交互作用P = 0.0204）。
该研究得出结论，ALI与胆结石呈正相关，且ALI对女性胆结石患病率的影响更大。
