Department of Community Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Clinical Nutrition and Dietetics Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences Tehran, Tehran, Iran.
BMC Gastroenterol. 2023 Sep 14;23(1):311. doi: 10.1186/s12876-023-02943-9.
Considering inflammation as a primary occurrence in gallstone formation, this study aimed to determine the relation between serum biomarkers of inflammation and oxidative stress, and dietary Inflammatory Index (DII) score with the risk of gallstone disease (GD) among Iranian women.
Present BMI-matched case-control study was performed among 75 women with GD and 75 healthy controls. Biochemical parameters were measured by standard laboratory methods. A validated food frequency questionnaire (FFQ) was used to assess the usual intake of participants. DII score was calculated for all participants. The linear and logistic regression were used to examine the association of DII with serum inflammatory biomarkers and the odds ratio of GD, respectively.
The mean serum levels of high-sensitivity C-reactive protein (hs-CRP) and Malondialdehyde (MDA) were significantly (P < 0.001) higher in GD patients compared to control subjects. Women in the highest tertile of DII compared to the lowest tertile had lower intake of macronutrients, minerals, vitamins garlic, onion, pepper and fiber. Moreover, the odd of GD was significantly higher in the third tertile of the DII versus the first tertile after adjustment of potential confounders (OR: 17.47; 95% CI: 4.64-65.72). Also, a positive and significant relationship was found between the serum level of inflammatory biomarkers with the risk of GD and the inflammatory score of the diet (P < 0.001).
Our data indicate that higher DII score, and serum inflammatory and oxidative stress biomarkers are related to higher risk of GD in Iranian women.
鉴于炎症是胆石形成的主要发生因素，本研究旨在确定血清炎症生物标志物和氧化应激与伊朗女性胆石病（GD）风险之间的关系，以及饮食炎症指数（DII）评分与 GD 风险之间的关系。
本研究为 BMI 匹配的病例对照研究，共纳入 75 名 GD 患者和 75 名健康对照者。采用标准实验室方法测定生化参数。采用经过验证的食物频率问卷（FFQ）评估参与者的常规饮食摄入量。计算所有参与者的 DII 评分。采用线性和逻辑回归分别检验 DII 与血清炎症生物标志物的关系以及 GD 的比值比。
与对照组相比，GD 患者的高敏 C 反应蛋白（hs-CRP）和丙二醛（MDA）血清水平显著升高（P < 0.001）。与 DII 评分最低组相比，DII 评分最高组的女性宏量营养素、矿物质、维生素大蒜、洋葱、胡椒和纤维的摄入量较低。此外，在调整潜在混杂因素后，DII 评分第三组与第一组相比，GD 的比值比显著更高（OR：17.47；95%CI：4.64-65.72）。此外，炎症生物标志物血清水平与 GD 风险和饮食炎症评分之间呈正相关且具有统计学意义（P < 0.001）。
我们的数据表明，较高的 DII 评分以及血清炎症和氧化应激生物标志物与伊朗女性 GD 风险增加相关。
