Meng Chunli, Liu Kai
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
Front Med (Lausanne). 2024 Jan 12;10:1320735. doi: 10.3389/fmed.2023.1320735. eCollection 2023.
Inflammation plays a significant role in gallstones formation. The prognosis of various illnesses was initially predicted using the systemic immune-inflammatory index (SII). We performed an updated analysis on the impact of SII and gallstones.
To investigate the connection between the SII and gallstones occurrence in a sample of individuals from the National Health and Nutrition Examination Survey (NHANES) database from 2017 to 2020, we employed logistic regression analysis, subgroup analysis, and smoothing curve fitting.
In our study, an aggregate of 4,950 individuals over the age of 20 were enrolled, and 429 of them claimed to have gallstones. A fully adjusted model showed that the third and fourth quartiles of SII was parallel associated with gallstones in adults (OR = 2.43, 95% CI = 1.39-4.26; OR = 2.97, 95% CI = 1.72-5.16) under 50 years. Subgroup analysis and smoothed curve fitting provided evidence in favor of this finding.
According to our research, gallstones are more likely to occur in US adults younger than 50 years.
炎症在胆结石形成过程中起着重要作用。各种疾病的预后最初是使用全身免疫炎症指数（SII）来预测的。我们对SII与胆结石的影响进行了最新分析。
为了研究2017年至2020年美国国家健康与营养检查调查（NHANES）数据库中个体样本的SII与胆结石发生之间的联系，我们采用了逻辑回归分析、亚组分析和平滑曲线拟合。
在我们的研究中，共纳入了4950名20岁以上的个体，其中429人声称患有胆结石。一个完全调整的模型显示，在50岁以下的成年人中，SII的第三和第四四分位数与胆结石呈平行相关（OR = 2.43，95% CI = 1.39 - 4.26；OR = 2.97，95% CI = 1.72 - 5.16）。亚组分析和平滑曲线拟合为这一发现提供了证据。
根据我们的研究，在美国50岁以下的成年人中，胆结石更易发生。
