Maurya Deepak, Mondal Bama Charan
Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
MicroPubl Biol. 2024 Dec 18;2024. doi: 10.17912/micropub.biology.001392. eCollection 2024.
Macrophages are present in various forms throughout metazoans and play conserved roles in phagocytosis, immunity, and tissue homeostasis. In s larval hematopoietic organ, the lymph gland, transient caspase-mediated activation of caspase-activated DNase triggers the DNA damage response (DDR), which is crucial for macrophage-type cell differentiation. Here, we report that other species having different-sized mature lymph glands show effector caspase activity and DDR similar to those in , indicating that the developmental mechanism regulating phagocytic macrophage differentiation is conserved in different species of .
巨噬细胞以多种形式存在于整个后生动物中，并在吞噬作用、免疫和组织稳态中发挥保守作用。在果蝇幼虫造血器官淋巴腺中，半胱天冬酶介导的半胱天冬酶激活的脱氧核糖核酸酶的瞬时激活触发了DNA损伤反应（DDR），这对巨噬细胞型细胞分化至关重要。在这里，我们报告说，其他具有不同大小成熟淋巴腺的物种显示出与果蝇中相似的效应半胱天冬酶活性和DDR，这表明调节吞噬性巨噬细胞分化的发育机制在不同果蝇物种中是保守的。
