Mehta Anish, Ng Samuel Y E, Neo Shermyn X M, Chia Nicole S Y, Saffari Ehsan S, Shivashanmugam Thyagarajan, Choi Xinyi, Heng Dede L, Xu Z Y, Tay K Y, Au W L, Tan E K, Tan Louis C S
Department of Neurology, National Neuroscience Institute, Singapore.
Department of Neurology, Ramaiah Medical College and Hospitals, Ramaiah University of Applied Sciences, Bengaluru, India.
Clin Park Relat Disord. 2024 Dec 9;12:100293. doi: 10.1016/j.prdoa.2024.100293. eCollection 2025.
COVID-19-related social restrictions provided an opportunity to evaluate the impact of social isolation on Parkinson's disease.
This study aimed to explore changes in social isolation and their associations with PD symptoms using the Lubben Social Network Scale-Revised (LSNS-R).
Data from 80 participants of the Early Parkinson's Disease Longitudinal Singapore cohort were collected from April 2019 to April 2023, covering the periods before and after the imposition of COVID-19 restrictions. Individuals with LSNS-R scores ≤ 24 were considered socially isolated. Data were stratified into strata 1 (improved LSNS-R scores) and strata 2 (worsened/unchanged scores). Linear regression was used to identify predictors of LSNS-R change, and MANCOVA was used to examine associations between LSNS-R change and motor/ non-motor symptoms.
Mean LSNS-R scores decreased (p = 0.014), and proportions of social isolation increased (p < 0. 001) during COVID-19 restrictions. However, 35 % showed improved LSNS-R scores, while 65 % had worsened/unchanged scores. The regression model was significant in strata 1 (R2 = 0.806, p = 0.001), with age, marital status, and social isolation status being significantly associated with change in LSNS-R scores. LSNS-R. Results of MANCOVA indicated that LSNS-R improvements in LSNS-R were significantly associated with outcomes (Roy's Largest Root statistic = 126.638, p < 0.001), particularly for changes in PDQ8, HADS-Anxiety, and HADS-Depression scores. The regression model was not significant in strata 2 (R2 = 0. 279, p = 0.206), wherein motor and non-motor symptoms worsened.
While worsening LSNS-R scores were associated with poorer outcomes, improvements in social networks were associated with improved non-motor symptoms and quality of life. These findings underscore the complexity of social isolation in PD and the need for targeted interventions.
与新冠疫情相关的社会限制措施为评估社会隔离对帕金森病的影响提供了契机。
本研究旨在使用修订版的鲁本社会网络量表（LSNS-R）探讨社会隔离的变化及其与帕金森病症状的关联。
收集了2019年4月至2023年4月期间新加坡帕金森病早期纵向队列研究中80名参与者的数据，涵盖了实施新冠疫情限制措施前后的时间段。LSNS-R得分≤24的个体被视为处于社会隔离状态。数据被分层为第1层（LSNS-R得分改善）和第2层（得分恶化/未改变）。使用线性回归来确定LSNS-R变化的预测因素，并使用多变量协方差分析来检验LSNS-R变化与运动/非运动症状之间的关联。
在新冠疫情限制期间，LSNS-R平均得分下降（p = 0.014），社会隔离比例增加（p < 0.001）。然而，35%的人LSNS-R得分有所改善，而65%的人得分恶化/未改变。回归模型在第1层具有显著性（R2 = 0.806，p = 0.001），年龄、婚姻状况和社会隔离状态与LSNS-R得分变化显著相关。多变量协方差分析结果表明，LSNS-R得分的改善与结果显著相关（Roy最大根统计量 = 126.638，p < 0.001），特别是对于帕金森病问卷8项（PDQ8）、医院焦虑抑郁量表-焦虑（HADS-焦虑）和医院焦虑抑郁量表-抑郁（HADS-抑郁）得分的变化。回归模型在第2层不具有显著性（R2 = 0.279，p = 0.206），其中运动和非运动症状恶化。
虽然LSNS-R得分恶化与较差的结果相关，但社交网络的改善与非运动症状和生活质量的改善相关。这些发现强调了帕金森病中社会隔离的复杂性以及针对性干预的必要性。
