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静脉注射脂质体两性霉素B联合口服氟胞嘧啶成功治疗脑室炎:一例报告

Successful Treatment of Ventriculitis With Intravenous Liposomal Amphotericin B and Oral Flucytosine: A Case Report.

作者信息

Kang Nayoung, Hsu Victor Yu-Ching, Bailey Charles Christopher

机构信息

Pharmacy Department, Providence St Joseph Hospital, Orange, California, USA.

Medicine Department, Providence St Joseph Hospital, Orange, California, USA.

出版信息

Open Forum Infect Dis. 2024 Dec 20;12(1):ofae743. doi: 10.1093/ofid/ofae743. eCollection 2025 Jan.

Abstract

is a rapidly emerging fungal pathogen associated with high resistance rates, particularly in healthcare settings. It most commonly affects patients with severe underlying medical conditions and requiring complex medical care. Patients with invasive medical devices tend to be at increased risk for getting and developing infection. This article presents a case of ventriculitis successfully treated with intravenous liposomal amphotericin B and oral flucytosine. A 41-year-old man with multiple comorbidities, including recent placement of a ventriculoperitoneal shunt, presented with suspected sepsis. was isolated from cerebrospinal fluid cultures. Antifungal therapy along with removal of the shunt led to resolution of infection without complications. This case highlights the challenges posed by infections and underscores the importance of appropriate treatment strategies.

摘要

是一种迅速出现的真菌病原体,耐药率高,尤其是在医疗环境中。它最常影响患有严重基础疾病且需要复杂医疗护理的患者。使用侵入性医疗设备的患者感染和发生感染的风险往往会增加。本文介绍了一例通过静脉注射脂质体两性霉素B和口服氟胞嘧啶成功治疗的脑室炎病例。一名41岁患有多种合并症的男子,包括最近放置了脑室腹腔分流管,出现疑似败血症。从脑脊液培养物中分离出[病原体名称未给出]。抗真菌治疗以及移除分流管导致感染消退且无并发症。该病例突出了[病原体名称未给出]感染带来的挑战,并强调了适当治疗策略的重要性。

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本文引用的文献

5
Successful treatment of shunt infection with intraventricular caspofungin.使用脑室内卡泊芬净成功治疗分流感染。
Med Mycol Case Rep. 2018 Aug 11;22:35-37. doi: 10.1016/j.mmcr.2018.08.005. eCollection 2018 Dec.
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CNS pharmacokinetics of antifungal agents.抗真菌药物的中枢神经系统药代动力学
Expert Opin Drug Metab Toxicol. 2007 Aug;3(4):573-81. doi: 10.1517/17425225.3.4.573.

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