使用脑室内卡泊芬净成功治疗分流感染。
Successful treatment of shunt infection with intraventricular caspofungin.
作者信息
Singhal Tanu, Kumar Abhaya, Borade Prashant, Shah Sweta, Soman Rajeev
机构信息
Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai 400053, India.
Jupiter Hospital, Pune, India.
出版信息
Med Mycol Case Rep. 2018 Aug 11;22:35-37. doi: 10.1016/j.mmcr.2018.08.005. eCollection 2018 Dec.
is an emerging fungal pathogen with high prevalence of resistance to current antifungal agents. Central nervous system infection with has been infrequently described. We describe here an adult with nosocomial CSF shunt infection due to multi drug resistant . Systemic therapy with echinocandin and flucytosine failed. Fortunately, administration of daily intraventricular caspofungin 10 mg for 10 days in conjunction with systemic voriconazole resulted in both clinical and microbiological cure.
是一种新兴的真菌病原体，对当前抗真菌药物的耐药性普遍较高。关于其引起的中枢神经系统感染的描述较少。我们在此描述一名因多重耐药菌引起医院获得性脑脊液分流感染的成年人。棘白菌素和氟胞嘧啶的全身治疗失败。幸运的是，每天脑室内注射10毫克卡泊芬净，持续10天，并联合全身应用伏立康唑，实现了临床和微生物学治愈。
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