Birkl Christoph, Filippi Vera, Steiger Ruth, Frank Florian, Magnesius Stephanie, Gizewski Elke R, Broessner Gregor
Department of Neuroradiology, Medical University of Innsbruck, Innsbruck, Austria.
Neuroimaging Research Core Facility, Medical University of Innsbruck, Innsbruck, Austria.
Front Neurol. 2024 Dec 20;15:1422313. doi: 10.3389/fneur.2024.1422313. eCollection 2024.
There is evidence that iron metabolism may play a role in the underlying pathophysiological mechanism of migraine. Studies using (=1/ ) relaxometry, a common MRI-based iron mapping technique, have reported increased values in various brain structures of migraineurs, indicating iron accumulation compared to healthy controls.
To investigate whether there are short-term changes in during a migraine attack.
26-year-old male patient diagnosed with episodic migraine with aura according to ICHD-3 criteria.
3 T, 64-channel head coil, for quantification of relaxation a multi-echo gradient echo (GRE) sequence with TE = 4.92, 9.84, 14.7, 19.6, 24.6 and 29.51 ms, TR = 35 ms, flip angle = 15°, and 0.9 × 0.9 × 0.9 mm isotropic resolution was used.
Quantitative MRI, including relaxometry and diffusion tensor imaging (DTI), was acquired from a migraine patient on 21 consecutive days, including migraine-free days and days with a migraine attack.
Statistical analysis was performed using R, the Shapiro-Wilk test, the -test and Mann Whitney test, analysis of variance (ANOVA) or Kruskal-Wallis test, depending on the distribution of the data. -value <0.05 was considered significant.
Significant difference in was found between the left and right hemispheres during a migraine attack. An increase in was observed in the left hemisphere, whereas in the right hemisphere was found to decrease. In the left cerebral white matter, increased by 1.8% ( = 0.021), in the right cerebral white matter, anisotropy decreased by 17% ( = 0.011) during a migraine attack.
Our study showed a decrease and increase in iron content during the migraine cycle. Furthermore, during a migraine attack, white matter iron content increased, accompanied by a decrease in anisotropic tissue components, suggesting additional changes in vascular components.
有证据表明铁代谢可能在偏头痛潜在的病理生理机制中起作用。使用磁共振弹性成像（MRE，一种基于MRI的常见铁映射技术）的研究报告称，偏头痛患者各种脑结构中的MRE值升高，表明与健康对照相比存在铁蓄积。
研究偏头痛发作期间MRE是否有短期变化。
一名26岁男性患者，根据国际头痛疾病分类第三版（ICHD-3）标准被诊断为伴有先兆的发作性偏头痛。
采用3T、64通道头部线圈，使用多回波梯度回波（GRE）序列进行MRE定量，TE = 4.92、9.84、14.7、19.6、24.6和29.51毫秒，TR = 35毫秒，翻转角 = 15°，各向同性分辨率为0.9×0.9×0.9毫米。
对一名偏头痛患者连续21天进行定量MRI检查，包括无偏头痛日和偏头痛发作日，检查内容包括MRE和扩散张量成像（DTI）。
根据数据分布，使用R软件进行统计分析，采用夏皮罗-威尔克检验、t检验和曼-惠特尼U检验、方差分析（ANOVA）或克鲁斯卡尔-沃利斯检验。P值<0.05被认为具有统计学意义。
在偏头痛发作期间，左右半球之间的MRE存在显著差异。左半球MRE升高，而右半球MRE降低。在偏头痛发作期间，左侧脑白质的MRE增加了1.8%（P = 0.021），右侧脑白质的MRE各向异性降低了17%（P = 0.011）。
我们的研究表明，在偏头痛周期中铁含量有降低和升高。此外，在偏头痛发作期间，白质铁含量增加，同时各向异性组织成分减少，提示血管成分有额外变化。
