Institute of Molecular Plus, Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Weijin Road 92, Tianjin 300072, China.
Zhejiang Institute of Tianjin University, Ningbo, Zhejiang 315201, China.
J Org Chem. 2021 Nov 5;86(21):15835-15844. doi: 10.1021/acs.joc.1c02027. Epub 2021 Oct 26.
A practical method to construct sulfenylated indole-fused isoquinolin-6(5)-one derivatives has been developed. Using eco-friendly ethanol as the solvent and air as the oxidant, this reaction could be compatible with sensitive molecular framework. The utility of the product was well illustrated by further transformations. Moreover, the reaction mechanism was investigated by control experiments.
一种实用的方法被开发用于构建亚磺酰化吲哚并异喹啉-6(5)-酮衍生物。该反应以环保的乙醇为溶剂，以空气为氧化剂，对敏感的分子骨架具有良好的兼容性。进一步的转化很好地说明了产物的实用性。此外，还通过对照实验研究了反应机理。
