Torkashvand Mohammad, Rezakhani Leila, Habibi Zahra, Mikaeili Abdolhamid, Rahmati Shima
College of Engineering, University of Tehran, Tehran, Iran.
Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Front Bioeng Biotechnol. 2024 Dec 20;12:1502155. doi: 10.3389/fbioe.2024.1502155. eCollection 2024.
Lung diseases account for over four million premature deaths every year, and experts predict that this number will increase in the future. The top cause of death globally is diseases which include conditions like lung cancer asthma and COPD. Treating severe acute lung injury is a complex task because lungs struggle to heal themselves in the presence of swelling inflammation and scarring caused by damage, to the lung tissues. Though achieving lung regeneration, in controlled environments is still an ambition; ongoing studies are concentrating on notable progress, in the field of lung tissue engineering and methods for repairing lung damage. This review delves into methods, for regenerating lungs with a focus on exosome carry bioscaffolds and mesenchymal stem cells among others. It talks about how these new techniques can help repair lung tissue and improve lung function in cases of damage. Also noted is the significance of lung perfusion (EVLP), for rejuvenating donor lungs and the healing properties of exosomes in supporting lung regeneration.
肺部疾病每年导致超过400万人过早死亡，专家预测这一数字未来还会增加。全球首要死因是包括肺癌、哮喘和慢性阻塞性肺疾病等在内的疾病。治疗严重急性肺损伤是一项复杂的任务，因为肺部在因肺组织损伤而出现肿胀、炎症和瘢痕形成的情况下难以自我修复。尽管在可控环境中实现肺再生仍是一个目标；目前的研究正专注于肺组织工程领域以及修复肺损伤方法方面的显著进展。本综述深入探讨了肺再生的方法，重点关注外泌体携带生物支架、间充质干细胞等。它讨论了这些新技术如何有助于在肺组织受损的情况下修复肺组织并改善肺功能。还提到了肺灌注（体外肺灌注）对于使供体肺恢复活力的重要性以及外泌体在支持肺再生方面的愈合特性。
