Cayuela Lucía, Gaeta Anna Michela, Piury-Pinzón Javier, Ortega-Calvo Manuel, Cayuela Aurelio
Department of Internal Medicine, Hospital Universitario Severo Ochoa, Leganés, Spain.
Pneumology Department, Hospital Universitario Severo Ochoa, Leganés, Spain.
Open Respir Arch. 2024 Nov 23;7(1):100390. doi: 10.1016/j.opresp.2024.100390. eCollection 2025 Jan-Mar.
Lung cancer remains one of the leading causes of cancer death worldwide. This study examines lung cancer mortality trends in Andalusia, Spain, from 2003 to 2022, focusing on gender differences and the influence of age, period and cohort effects.
This longitudinal ecological study analyzed lung cancer mortality data in Andalusia from 2003 to 2022, using age-period-cohort (A-P-C) and joinpoint regression models. Mortality rates were calculated by sex, age group, and standardized to the 2013 European Standard Population.
Between 2003 and 2022, Andalusia recorded 68,480 lung cancer deaths, with a significant gender disparity. Male mortality decreased (-1.9%), while female mortality increased (3.5%). Joinpoint analysis revealed a notable rise in female mortality rates after 2015. Age-specific analyses showed decreasing rates for men across all age groups, with a sharper decline for younger men. Women experienced increasing rates, particularly among those aged 35-64. The A-P-C model identified significant cohort effects, with decreasing rate ratios for men and increasing ones for women, reflecting historical smoking patterns.
Lung cancer mortality in Andalusia has exhibited a stark gender divide, reflecting the region's historical smoking patterns. While declining rates among men and younger women indicate the efficacy of tobacco control measures, the persistent rise in female mortality underscores the enduring effects of past smoking habits. These findings emphasize the imperative for ongoing public health initiatives and gender-specific interventions to mitigate the burden of lung cancer in Andalusia.
肺癌仍然是全球癌症死亡的主要原因之一。本研究考察了2003年至2022年西班牙安达卢西亚的肺癌死亡率趋势，重点关注性别差异以及年龄、时期和队列效应的影响。
这项纵向生态学研究使用年龄-时期-队列（A-P-C）模型和连接点回归模型，分析了安达卢西亚2003年至2022年的肺癌死亡率数据。死亡率按性别、年龄组计算，并根据2013年欧洲标准人口进行标准化。
2003年至2022年期间，安达卢西亚有68480例肺癌死亡病例，存在显著的性别差异。男性死亡率下降了（-1.9%），而女性死亡率上升了（3.5%）。连接点分析显示，2015年后女性死亡率显著上升。按年龄组分析显示，所有年龄组的男性死亡率均呈下降趋势，年轻男性下降更为明显。女性死亡率呈上升趋势，尤其是在35-64岁的女性中。A-P-C模型确定了显著的队列效应，男性的率比下降，女性的率比上升，反映了历史吸烟模式。
安达卢西亚的肺癌死亡率呈现出明显的性别差异，反映了该地区的历史吸烟模式。男性和年轻女性死亡率的下降表明烟草控制措施的有效性，而女性死亡率的持续上升凸显了过去吸烟习惯的持久影响。这些发现强调了持续开展公共卫生举措和针对性别的干预措施以减轻安达卢西亚肺癌负担的必要性。
