Department of Thoracic Surgery, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, 20141, Milan, Italy.
Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Updates Surg. 2024 Oct;76(6):2129-2140. doi: 10.1007/s13304-024-01841-3. Epub 2024 Apr 6.
Lung cancer, a multifaceted disease, demands tailored therapeutic approaches due to its diverse subtypes and stages. This comprehensive review explores the intricate landscape of lung cancer research, delving into recent breakthroughs and their implications for diagnosis, therapy, and prevention. Genomic profiling and biomarker identification have ushered in the era of personalised medicine, enabling targeted therapies that minimise harm to healthy tissues while effectively combating cancer cells. The relationship between pulmonary tuberculosis and lung cancer is examined, shedding light on potential mechanisms linking these two conditions. Early detection methods, notably low-dose computed tomography scans, have significantly improved patient outcomes, emphasising the importance of timely interventions. There has been a growing interest in segmentectomy as a surgical intervention for early-stage lung cancer in recent years. Immunotherapy has emerged as a transformative approach, harnessing the body's immune system to recognise and eliminate cancer cells. Combining immunotherapy with traditional treatments, such as chemotherapy and targeted therapies, has shown enhanced efficacy, addressing the disease's heterogeneity and overcoming drug resistance. Precision medicine, guided by genomic profiling, has enabled the development of targeted therapies like tyrosine kinase inhibitors, offering personalised treatments tailored to individual patients. Challenges such as drug resistance and limited accessibility to advanced therapies persist, emphasising the need for collaborative efforts and innovative technologies like artificial intelligence. Despite challenges, ongoing interdisciplinary collaborations and technological advancements offer hope for a future where lung cancer is treatable and preventable, reducing the burden on patients and healthcare systems worldwide.
肺癌是一种多方面的疾病,由于其不同的亚型和阶段,需要量身定制的治疗方法。本综述深入探讨了肺癌研究的复杂领域,探讨了最近的突破及其对诊断、治疗和预防的影响。基因组分析和生物标志物的鉴定开创了个性化医疗的时代,使靶向治疗能够最大限度地减少对健康组织的伤害,同时有效地对抗癌细胞。还研究了肺结核与肺癌之间的关系,揭示了这两种疾病之间潜在的联系机制。近年来,早期检测方法,特别是低剂量计算机断层扫描,显著改善了患者的预后,强调了及时干预的重要性。在过去几年中,段切除术作为早期肺癌的一种手术干预方式越来越受到关注。免疫疗法已成为一种变革性的方法,利用人体的免疫系统来识别和消除癌细胞。免疫疗法与传统治疗方法(如化疗和靶向治疗)相结合,已显示出增强的疗效,解决了疾病的异质性和克服了耐药性问题。基于基因组分析的精准医疗已经能够开发出针对特定患者的治疗药物,如酪氨酸激酶抑制剂等靶向疗法。尽管存在挑战,但持续的跨学科合作和技术进步为未来提供了希望,即肺癌可以得到治疗和预防,减轻全球患者和医疗系统的负担。