Analysis of risk factors for abnormal renal function in patients with gout in Southwest China: a cross-sectional study.

OBJECTIVE

To analyse the associations between renal function and clinical laboratory indicators and explore the renal function abnormality risk factors for gout patients in Southwest China.

METHODS

Outpatient and hospitalized gout patients ( = 4384) at the First Affiliated Hospital of Chengdu Medical College between January 2017 and December 2020 were divided into normal ( = 2393) and abnormal ( = 1991) renal function groups according to their eGFR. The relationships between clinical laboratory indicators and the eGFR were analysed, and a logistic regression model was fit to identify significant risk factors.

RESULTS

Sex, age, absolute lymphocyte count (ALC), cystatin C (CysC), homocysteine (Hcy) and thyroid stimulating hormone (TSH) were associated with renal function abnormalities ( < 0.05), whereas age [odds ratio (95% CI) = 1.06 (1.05-1.08),  < 0.001], Hcy [1.02 (1.00-1.04),  = 0.028], CysC [1.72 (1.54-1.92),  < 0.001], ALC [0.71 (0.52-0.97),  = 0.03] and TSH [1.08 (1.00-1.17),  = 0.049] were abnormal renal function risk factors for gout patients. After stratification by UA, binary logistic regression analysis identified the following risk factors: Q1 age [1.06 (1.02-1.11),  = 0.003], CysC [1.67 (1.30-2.16),  < 0.001]; Q2 age [1.09 (1.06-1.12),  < 0.001], CysC [1.55 (1.28-1.88),  < 0.001], FT3 [0.66 (0.46-0.96),  = 0.029]; Q3 age [1.06 (1.03-1.09),  < 0.001], CysC [1.75 (1.41-2.18),  < 0.001], Hcy [1.04 (1.00-1.08),  = 0.047], ALC [0.35 (0.18-0.69),  = 0.002]; Q4 age [1.05 (1.02-1.09),  = 0.004], CysC [1.79 (1.40-2.30),  < 0.001].

CONCLUSION

ALC and levels of TSH and serum Cys could be used for monitoring for abnormal renal function in patients with gout.