Beckish Lauren, Ging Madison, Mosman Maria, Kelley Cody, Wilkin Landree, Wills Olivia, Adams Madison, Pinion Cassidy, Bilica Cheyenne, Anderson Alavia, Sims Margaret, Beckish Michael, Schmitt Deanna M
Department of Physician Assistant Studies, West Liberty University, West Liberty, WV, United States of America.
Department of Orthopedics, Prisma Health - Upstate, Greenville, SC, United States of America.
J Orthop Physician Assist. 2024 Jul-Sep;12(3). doi: 10.2106/jbjs.jopa.24.00013.
Legg-Calvé-Perthes Disease (LCPD) is a condition marked by temporary blood flow disruption to the proximal femur, commonly afflicting children aged 15 and younger. The etiology of the disease is often idiopathic and involves the development of avascular necrosis of the femoral head, subsequently leading to bone weakening and deformity. Obesity exacerbates LCPD, correlating with delayed diagnosis, increased disease severity, and bilateral involvement. Leptin, growth hormone, and other inflammatory mediator alterations in obese individuals contribute to the pathogenesis. Treatment ranges from conservative measures to surgery, with particular challenges in obese patients. An improved understanding of the impact of obesity on LCPD progression is crucial for tailored management and optimal outcomes.
Legg-Calvé-Perthes病（LCPD）是一种以近端股骨暂时血流中断为特征的疾病，常见于15岁及以下儿童。该病的病因通常是一种以近端股骨暂时血流中断为特征的疾病，常见于15岁及以下儿童。该病病因通常不明，涉及股骨头缺血性坏死的发展，随后导致骨骼弱化和畸形。肥胖会加重LCPD，与诊断延迟、疾病严重程度增加和双侧受累相关。肥胖个体中瘦素、生长激素和其他炎症介质的改变有助于发病机制。治疗方法从保守措施到手术不等，肥胖患者面临特殊挑战。更好地理解肥胖对LCPD进展的影响对于制定个性化管理方案和实现最佳治疗效果至关重要。
