Suppr超能文献

肥胖儿童人群中Legg-Calvé-Perthes病的诊断与管理

Diagnosis and Management of Legg-Calvé-Perthes Disease in the Obese Pediatric Population.

作者信息

Beckish Lauren, Ging Madison, Mosman Maria, Kelley Cody, Wilkin Landree, Wills Olivia, Adams Madison, Pinion Cassidy, Bilica Cheyenne, Anderson Alavia, Sims Margaret, Beckish Michael, Schmitt Deanna M

机构信息

Department of Physician Assistant Studies, West Liberty University, West Liberty, WV, United States of America.

Department of Orthopedics, Prisma Health - Upstate, Greenville, SC, United States of America.

出版信息

J Orthop Physician Assist. 2024 Jul-Sep;12(3). doi: 10.2106/jbjs.jopa.24.00013.

Abstract

Legg-Calvé-Perthes Disease (LCPD) is a condition marked by temporary blood flow disruption to the proximal femur, commonly afflicting children aged 15 and younger. The etiology of the disease is often idiopathic and involves the development of avascular necrosis of the femoral head, subsequently leading to bone weakening and deformity. Obesity exacerbates LCPD, correlating with delayed diagnosis, increased disease severity, and bilateral involvement. Leptin, growth hormone, and other inflammatory mediator alterations in obese individuals contribute to the pathogenesis. Treatment ranges from conservative measures to surgery, with particular challenges in obese patients. An improved understanding of the impact of obesity on LCPD progression is crucial for tailored management and optimal outcomes.

摘要

Legg-Calvé-Perthes病(LCPD)是一种以近端股骨暂时血流中断为特征的疾病,常见于15岁及以下儿童。该病的病因通常是一种以近端股骨暂时血流中断为特征的疾病,常见于15岁及以下儿童。该病病因通常不明,涉及股骨头缺血性坏死的发展,随后导致骨骼弱化和畸形。肥胖会加重LCPD,与诊断延迟、疾病严重程度增加和双侧受累相关。肥胖个体中瘦素、生长激素和其他炎症介质的改变有助于发病机制。治疗方法从保守措施到手术不等,肥胖患者面临特殊挑战。更好地理解肥胖对LCPD进展的影响对于制定个性化管理方案和实现最佳治疗效果至关重要。

相似文献

4
Prognostic Significance of Metaphyseal Changes in Legg-Calvé-Perthes Disease.Legg-Calvé-Perthes病干骺端改变的预后意义
J Pediatr Orthop. 2025 Oct 1;45(9):e818-e825. doi: 10.1097/BPO.0000000000003032. Epub 2025 Jun 20.

本文引用的文献

5
Molecular Biomarkers in Perthes Disease: A Review.佩特兹病中的分子生物标志物:综述
Diagnostics (Basel). 2023 Jan 27;13(3):471. doi: 10.3390/diagnostics13030471.
7
Legg-Calvé-Perthes disease overview.Legg-Calvé-Perthes 病概述。
Orphanet J Rare Dis. 2022 Mar 15;17(1):125. doi: 10.1186/s13023-022-02275-z.
8
Leptin as a key regulator of the adipose organ.瘦素作为脂肪组织的关键调节因子。
Rev Endocr Metab Disord. 2022 Feb;23(1):13-30. doi: 10.1007/s11154-021-09687-5. Epub 2021 Sep 14.
9
Obesity, Adipose Tissue and Vascular Dysfunction.肥胖、脂肪组织与血管功能障碍。
Circ Res. 2021 Apr 2;128(7):951-968. doi: 10.1161/CIRCRESAHA.121.318093. Epub 2021 Apr 1.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验