Zhu Hai, Wang Yaping, Zhang Yu, Tian Yun, Liu Duan, Li Xiabing, Ji Gaili, Ma Caixia, Li Hongyu
Gynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Zhengzhou Key Laboratory of Gynecological Oncology, Zhengzhou, 450052, Henan, China.
Heliyon. 2024 Dec 9;10(24):e40966. doi: 10.1016/j.heliyon.2024.e40966. eCollection 2024 Dec 30.
Cervical cancer (CC), which ranks among the four most common cancers in women, is a leading cause of both illness and death globally. It's urgent to identify a new biomarker to elucidate the potential mechanisms underlying the progression of CC. Here, we screened the differentially expressed genes (DEGs) in the Cancer Genome Atlas database (TCGA) and selected Chromosome 1 open reading frame 74 (C1orf74) for further investigation. C1orf74 levels were elevated, indicating a link to poor prognosis. Higher expression of C1orf74 was significantly related to clinical stage, T stage, histological type and survival status. Functional enrichment analysis indicated that C1orf74 is likely associated with the MAPK signaling pathway. Moreover, we found that C1orf74 was correlated with multifarious immune cell infiltration. Finally, the knockdown of C1orf74 significantly inhibited the growth of CC in vitro. In conclusion, C1orf74 promotes CC proliferation and progression, is closely associated with poor prognosis, and plays a role in the tumor immune microenvironment. The research indicates that C1orf74 is important for treating CC and may help develop new strategies to improve patient outcomes.
宫颈癌（CC）是全球女性中四种最常见的癌症之一，是导致全球疾病和死亡的主要原因。迫切需要鉴定一种新的生物标志物，以阐明CC进展的潜在机制。在此，我们在癌症基因组图谱数据库（TCGA）中筛选了差异表达基因（DEG），并选择了1号染色体开放阅读框74（C1orf74）进行进一步研究。C1orf74水平升高，表明与预后不良有关。C1orf74的高表达与临床分期、T分期、组织学类型和生存状态显著相关。功能富集分析表明，C1orf74可能与丝裂原活化蛋白激酶（MAPK）信号通路相关。此外，我们发现C1orf74与多种免疫细胞浸润相关。最后，敲低C1orf74可显著抑制CC在体外的生长。总之，C1orf74促进CC增殖和进展，与预后不良密切相关，并在肿瘤免疫微环境中发挥作用。该研究表明，C1orf74对CC治疗具有重要意义，可能有助于制定改善患者预后的新策略。
