Application of Monte Carlo simulation and artificial neural network model to probabilistic health risk assessment in fluoride-endemic areas.

Groundwater contamination with fluoride is a considerable public health concern that affects millions of people worldwide. The rapid growth of urbanization has led to increase in groundwater contamination. The health risk assessment focuses on both acute and chronic health consequences as it investigates the extent and effects of fluoride exposure through contaminated groundwater. Fluoride exposure, especially in endemic locations, has serious health consequences, including dental and skeletal fluorosis. An accurate assessment of these hazards is essential for public health planning and mitigation actions. The present study uses Monte Carlo Simulation (MCS) and an Artificial Neural Network (ANN) model to perform a Probabilistic Health Risk Assessment on populations in fluoride-endemic areas. Analysis of the results of the study reveals that the concentration of fluoride ranged from 0.58 to 3.80 mg/L with an average of 2.30 mg/L across the Kasganj district, which was higher than permissible limits given by BIS and WHO. The highest value of hazard quotient of 3.29 for Children is found to be in the Durga Colony area, while the lowest value of the hazard quotient of 0.31 for adults is found to be in the Nadrai Gate area. The assessment of health risks revealed a high probability of non-carcinogenic disease from the consumption of groundwater containing fluoride. The ANN model has the R value of 0.9989 in training and 0.9870 in testing while RMSE value in training and testing was 0.02230 and 0.0267. The findings suggest that before being used, the groundwater in Kasganj, Uttar Pradesh, India, needs to be treated and made drinkable. The results emphasize the critical need for ongoing monitoring, public education initiatives, and implementing feasible mitigating techniques to lower fluoride exposure. The findings show that this hybrid model is excellent at addressing the numerous uncertainties associated with fluoride use, hence improving the reliability of health risk estimates in fluoride-endemic locations. The results offer vital information to help policymakers and local health officials create focused measures to safeguard public health in Kasganj.