Kovács Krisztián, Váncsa Szilárd, Agócs Gergely, Harnos Andrea, Hegyi Péter, Weninger Viktor, Baross Katinka, Kovács Bence, Soós Gergely, Kocsis György
Department of Orthopaedics Semmelweis University Budapest Hungary.
Centre for Translational Medicine Semmelweis University Budapest Hungary.
JBMR Plus. 2023 Oct 31;7(12):e10835. doi: 10.1002/jbm4.10835. eCollection 2023 Dec.
The importance of finite element analysis (FEA) is growing in orthopedic research, especially in implant design. However, Young's modulus () values, one of the most fundamental parameters, can range across a wide scale. Therefore, our study aimed to identify factors influencing values in human bone specimens. We report our systematic review and meta-analysis based on the recommendation of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guideline. We conducted the analysis on November 21, 2021. We included studies investigating healthy human bone specimens and reported on values regarding demographic data, specimen characteristics, and measurement specifics. In addition, we included study types reporting individual specimen measurements. From the acquired data, we created a cohort in which we performed an exploratory data analysis that included the explanatory variables selected by random forest and regression trees methods, and the comparison of groups using independent samples Welch's test. A total of 756 entries were included from 48 articles. Eleven different bones of the human body were included in these articles. The range of values is between 0.008 and 33.7 GPa. The values were most heavily influenced by the cortical or cancellous type of bone tested. Measuring method (compression, tension, bending, and nanoindentation), the anatomical region within a bone, the position of the bone within the skeleton, and the bone specimen size had a decreasing impact on the values. Bone anisotropy, specimen condition, patient age, and sex were selected as important variables considering the value of . On the basis of our results, values of a bone change with bone characteristics, measurement techniques, and demographic variables. Therefore, the evaluation of FEA should be performed after the standardization of in vitro measurement protocol. © 2023 The Authors. published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
有限元分析（FEA）在骨科研究中的重要性日益增加，尤其是在植入物设计方面。然而，杨氏模量（）值作为最基本的参数之一，其范围跨度很大。因此，我们的研究旨在确定影响人体骨标本中值的因素。我们根据《系统评价和荟萃分析优先报告项目》（PRISMA）2020指南的建议报告了我们的系统评价和荟萃分析。我们于2021年11月21日进行了分析。我们纳入了调查健康人体骨标本的研究，并报告了有关人口统计学数据、标本特征和测量细节的值。此外，我们纳入了报告单个标本测量值的研究类型。从获取的数据中，我们创建了一个队列，在其中进行了探索性数据分析，包括通过随机森林和回归树方法选择的解释变量，以及使用独立样本韦尔奇检验进行组间比较。48篇文章共纳入756条记录。这些文章中包括了人体的11种不同骨骼。值的范围在0.008至33.7 GPa之间。值受所测试的皮质骨或松质骨类型影响最大。测量方法（压缩、拉伸、弯曲和纳米压痕）、骨内的解剖区域、骨骼内骨的位置以及骨标本大小对值的影响依次减小。考虑到值，骨各向异性、标本状况、患者年龄和性别被选为重要变量。根据我们的结果，骨的值会随骨特征、测量技术和人口统计学变量而变化。因此，应在体外测量方案标准化后进行有限元分析评估。© 2023作者。由Wiley Periodicals LLC代表美国骨与矿物质研究学会出版。
