Siretskiy Rachel, Motta Monique, Aitken Gabriela, Spector Chelsea, Rojas Claudia, Whitehouse Jill
Surgery, Florida International University, Herbert Wertheim College of Medicine, Miami, USA.
Pediatrics, Joe DiMaggio Children's Hospital, Hollywood, USA.
Cureus. 2024 Dec 4;16(12):e75114. doi: 10.7759/cureus.75114. eCollection 2024 Dec.
Hepatoblastoma is a rare pediatric cancer. Hepatoblastoma typically presents asymptomatically with an enlarging abdominal mass but can be associated with paraneoplastic secretion of beta-gonadotropin leading it to present like peripheral precocious puberty. This case highlights a rare initial presentation of hepatoblastoma as precocious puberty in a two-year-old patient who presented with persistent abdominal and genital pain. The patient was treated with right hepatic lobectomy and subsequently two cycles of cisplatin and was considered to be in remission without concern for recurrent disease. Considering that there have been more reports of this pathology in recent years, it is crucial to discuss the presentation, diagnosis, and treatment of this pathology. This case emphasizes the importance of maintaining hepatoblastoma as a differential diagnosis when evaluating precocious puberty and abdominal pain to avoid delays in diagnosis and treatment. This article also highlights our team's approach to the workup and treatment of this pathology, which can serve as a roadmap for other clinicians.
肝母细胞瘤是一种罕见的儿童癌症。肝母细胞瘤通常无症状，表现为腹部肿块增大，但可伴有β-促性腺激素的副肿瘤性分泌，导致其表现为外周性性早熟。本病例突出了肝母细胞瘤在一名两岁患者中罕见地以性早熟为首发表现，该患者伴有持续性腹痛和生殖器疼痛。患者接受了右肝叶切除术，随后进行了两个周期的顺铂治疗，被认为处于缓解期，无需担心疾病复发。鉴于近年来关于这种病理的报道增多，讨论这种病理的表现、诊断和治疗至关重要。本病例强调了在评估性早熟和腹痛时将肝母细胞瘤作为鉴别诊断的重要性，以避免诊断和治疗延误。本文还突出了我们团队对这种病理的检查和治疗方法，可为其他临床医生提供路线图。
