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紫茶(阿萨姆变种茶树)叶与肥胖管理:对1,2-二没食子酰基-4,6-六羟基二苯甲酰基-β-D-葡萄糖(GHG)潜在健康益处及未来前景的综述

Purple Tea (Camellia sinensis var. assamica) Leaves and Obesity Management: A Review of 1,2-Di-Galloyl-4,6-Hexahydroxydiphenoyl-β-D-Glucose's (GHG) Potential Health Benefits, and Future Prospects.

作者信息

Balasubramaniam Arun Kumar, Elangovan Ashmitha, Rahman Maheen Abdul, Nayak Subhendu, Richards Aleksander, Swain Durga

机构信息

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, USA.

Department of Zoology, PSGR Krishnammal College for Women, Coimbatore, IND.

出版信息

Cureus. 2024 Dec 3;16(12):e75055. doi: 10.7759/cureus.75055. eCollection 2024 Dec.

Abstract

Purple tea ( var. ) is a distinct variety of  known for its bioactive compounds, including caffeine, catechins, and a unique compound called 1,2-di-Galloyl-4,6-Hexahydroxydiphenoyl-β-D-Glucose, (GHG) found predominantly in purple tea leaves, which shows potential in obesity management. Studies have indicated that these bioactive compounds play a significant role in reducing BMI and body weight among obese patients. This review focuses on how GHG impacts body weight and BMI in obese patients. A comprehensive literature review was conducted using Science Direct, Semantic Scholar, Wiley, PubMed, and Google Scholar databases up to 2024. The search employed both single keywords (e.g., 'purple tea', 'GHG', 'obesity') and multiple keyword combinations (e.g., 'purple tea and obesity', 'GHG and weight loss') related to purple tea, GHG, obesity, BMI, and clinical studies. The database search yielded 246 articles, with 173 articles retained after removing duplicates and studies published before 1999. This systematic approach aimed to gather comprehensive data on the phytochemistry, pharmacology, and potential therapeutic applications of purple tea. The investigation revealed that GHG operates through multiple mechanisms, such as inhibiting pancreatic lipase to reduce fat absorption, suppressing adipogenesis and lipogenesis, and preventing fatty tissue formation. Clinical investigations demonstrated significant reductions in BMI, waist circumference, and body weight among individuals consuming purple tea extracts with high GHG levels. Additional metabolic benefits include increased energy expenditure, improved insulin sensitivity, and enhanced glucose metabolism regulation. While more comprehensive research is needed to fully elucidate the optimal dosage and long-term effects, current evidence suggests that GHG from purple tea could be a valuable natural intervention in the multifaceted approach to obesity management.

摘要

紫茶(变种)是茶树的一个独特品种,以其生物活性化合物而闻名,这些化合物包括咖啡因、儿茶素,以及一种主要存在于紫茶叶片中的名为1,2-二没食子酰基-4,6-六羟基二苯甲酰基-β-D-葡萄糖(GHG)的独特化合物,该化合物在肥胖管理方面显示出潜力。研究表明,这些生物活性化合物在降低肥胖患者的体重指数(BMI)和体重方面发挥着重要作用。本综述重点关注GHG如何影响肥胖患者的体重和BMI。使用Science Direct、Semantic Scholar、Wiley、PubMed和Google Scholar数据库进行了全面的文献综述,截至2024年。搜索使用了与紫茶、GHG、肥胖、BMI和临床研究相关的单个关键词(如“紫茶”、“GHG”、“肥胖”)和多个关键词组合(如“紫茶与肥胖”、“GHG与减肥”)。数据库搜索产生了246篇文章,在去除重复项和1999年之前发表的研究后,保留了173篇文章。这种系统的方法旨在收集有关紫茶的植物化学、药理学和潜在治疗应用的全面数据。调查显示,GHG通过多种机制发挥作用,如抑制胰脂肪酶以减少脂肪吸收、抑制脂肪生成和脂质生成,以及防止脂肪组织形成。临床研究表明,食用高GHG水平紫茶提取物的个体的BMI、腰围和体重显著降低。其他代谢益处包括增加能量消耗、改善胰岛素敏感性和增强葡萄糖代谢调节。虽然需要更全面的研究来充分阐明最佳剂量和长期效果,但目前的证据表明,紫茶中的GHG可能是肥胖管理多方面方法中的一种有价值的自然干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c5a/11698542/bab04a184914/cureus-0016-00000075055-i01.jpg

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