Laudani Samuele, Godos Justyna, Di Domenico Federica Martina, Barbagallo Ignazio, Randazzo Cinzia Lucia, Leggio Gian Marco, Galvano Fabio, Grosso Giuseppe
Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
Department of Agriculture, Food and Environment, University of Catania, 95123 Catania, Italy.
Antioxidants (Basel). 2023 Sep 18;12(9):1773. doi: 10.3390/antiox12091773.
Hypertension and derived cardiovascular disease (CVD) are among the leading causes of death worldwide. Increased oxidative stress and inflammatory state are involved in different alterations in endothelial functions that contribute to the onset of CVD. Polyphenols, and in particular anthocyanins, have aroused great interest for their antioxidant effects and their cardioprotective role. However, anthocyanins are rarely detected in blood serum because they are primarily metabolized by the gut microbiota. This review presents studies published to date that report the main results from clinical studies on the cardioprotective effects of anthocyanins and the role of the gut microbiota in the metabolism and bioavailability of anthocyanins and their influence on the composition of the microbiota. Even if it seems that anthocyanins have a significant effect on vascular health, more studies are required to better clarify which molecules and doses show vascular benefits without forgetting the crucial role of the microbiota.
高血压及由此引发的心血管疾病（CVD）是全球主要死因之一。氧化应激增加和炎症状态参与了内皮功能的不同改变，这些改变促成了心血管疾病的发生。多酚类物质，尤其是花青素，因其抗氧化作用和心脏保护作用而引起了极大关注。然而，血清中很少检测到花青素，因为它们主要由肠道微生物群代谢。本综述介绍了迄今为止发表的研究，这些研究报告了关于花青素心脏保护作用的临床研究主要结果，以及肠道微生物群在花青素代谢、生物利用度及其对微生物群组成影响方面的作用。即使花青素似乎对血管健康有显著影响，但仍需要更多研究来更好地阐明哪些分子和剂量能显示出血管益处，同时也不能忽视微生物群的关键作用。
