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Magnetic field-induced synergistic therapy of cancer using magnetoplasmonic nanoplatform.

作者信息

Gao Siqi, Golovynska Iuliia, Liu Jiantao, Huang Zhenlong, Xu Hao, Qu Jinghan, Lin Fangrui, Ostrovska Galyna, Qu Junle, Ohulchanskyy Tymish Y

机构信息

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.

Institute of Biology and Medicine, Taras Shevchenko National University of Kyiv, Kyiv, 01601, Ukraine.

出版信息

Mater Today Bio. 2024 Dec 7;30:101393. doi: 10.1016/j.mtbio.2024.101393. eCollection 2025 Feb.


DOI:10.1016/j.mtbio.2024.101393
PMID:39759844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11697064/
Abstract

Combining photothermal and chemotherapy using single nanoplatform is an emerging direction in cancer nanomedicine. Herein, a magnetic field (MF) induced combination of chemo/photothermal therapy is demonstrated using FeO@mSiO@Au core@shell@satellites nanoparticles (NPs) loaded with chemotherapeutic drug doxorubicin (DOX), both and An application of an external MF to the NPs dispersion causes magnetophoretic movement and aggregation of the NPs. While the synthesized NPs only slightly absorb light at ∼800 nm, their aggregation results in a significant near infrared (NIR) absorption associated with plasmon resonance coupling between the Au satellites in the NPs aggregates. As a result, the aggregates revealed an enhanced photothermal conversion efficiency (∼67 % versus ∼19 % for NPs in absence of MF) and an enhanced NIR photothermal effect was observed under 808 nm laser irradiation. A combination of the MF induced NIR photothermal therapy (PTT) with DOX chemotherapeutic action resulted in an efficient killing of NPs treated cancer cells and tumor growth restriction in 4T1-tumor-bearing mice . Histological studies showed striking differences in development and malignancy between tumors treated with the combination of NPs, MF and an 808 nm laser, and the control treatments, revealing a synergy of the MF-induced NIR PTT and chemotherapy and suggesting a promising strategy for cancer therapy.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/33b6dc4fd417/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/da80eb257f8c/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/c1e1900db487/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/808c678dec49/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/64cddf7f37d5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/7a834e9bfb61/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/e12bb0c4a422/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/6305ade2667c/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/19078ebaf6f8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/33b6dc4fd417/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/da80eb257f8c/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/c1e1900db487/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/808c678dec49/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/64cddf7f37d5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/7a834e9bfb61/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/e12bb0c4a422/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/6305ade2667c/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/19078ebaf6f8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/835f/11697064/33b6dc4fd417/gr7.jpg

相似文献

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Magnetic field-induced synergistic therapy of cancer using magnetoplasmonic nanoplatform.

Mater Today Bio. 2024-12-7

[2]
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[4]
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[6]
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[7]
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[8]
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[10]
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本文引用的文献

[1]
Confined semiconducting polymers with boosted NIR light-triggered HO production for hypoxia-tolerant persistent photodynamic therapy.

Chem Sci. 2024-7-4

[2]
Size-dependent magnetomechanically enhanced photothermal antibacterial effect of FeO@Au/PDA nanodurian.

Dalton Trans. 2023-11-28

[3]
Mechanism and effects of extramedullary hematopoiesis on anti-tumor immunity.

Cancer Biol Med. 2023-7-24

[4]
Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine.

ACS Nano. 2023-5-9

[5]
Recent advances in plasmon-enhanced luminescence for biosensing and bioimaging.

Anal Chim Acta. 2023-5-8

[6]
Synthesis of Multi-Stimuli Responsive FeO Coated with Diamonds Nanocomposite for Magnetic Assisted Chemo-Photothermal Therapy.

Molecules. 2023-2-13

[7]
Multifunctional Superparticles for Magnetically Targeted NIR-II Imaging and Photodynamic Therapy.

Adv Sci (Weinh). 2023-1

[8]
Cancer-Associated Fibroblasts: Tumorigenicity and Targeting for Cancer Therapy.

Cancers (Basel). 2022-8-12

[9]
Immunomodulation and delivery of macrophages using nano-smooth drug-loaded magnetic microrobots for dual targeting cancer therapy.

iScience. 2022-6-2

[10]
Star-Shaped Magnetic-Plasmonic Au@FeO Nano-Heterostructures for Photothermal Therapy.

ACS Appl Mater Interfaces. 2022-6-29

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