Wu Jing, Zhong Kai, Yang Hongyi, Zhang Peiliang, Yu Nianjun, Chen Weidong, Zhang Na, Gui Shuangying, Han Lan, Peng Daiyin
College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China.
Department of Biomedical Engineering, Institute of Advanced Clinical Medicine, Peking University, Beijing, 100191, China.
J Pharm Anal. 2024 Nov;14(11):101019. doi: 10.1016/j.jpha.2024.101019. Epub 2024 Jun 8.
The quality of Chinese materia medica (CMM) is a challenging and focused topic in the modernization of traditional Chinese medicine (TCM). A profound comprehension of the morphology, structure, active constituents, and dynamic changes during the whole process of CMM growth is essential, which needs highly precise contemporary techniques for in-depth elucidation. Magnetic resonance imaging (MRI) is a cutting-edge tool integrating the benefits of both nuclear magnetic resonance (NMR) spectroscopy and imaging technology. With real-time, non-destructive, and detection capabilities, MRI has been previously used for monitoring internal and external structures of plants alongside compounds during physiological processes . Here, factors involved in the holistic quality evaluation of CMMs were investigated. Given the applications of MRI in various plants, several representative CMMs were used as examples to demonstrate a methodology of quality visualization by MRI, embodying holistically monitoring the real-time macroscopic morphology, mesoscopic structure, and microscopic metabolites non-destructively . Taken together, the review not only presents a pioneering application mode for utilizing MRI for CMM quality visualization but also holds promise for advancing the quality control and evaluation of CMMs.
中药质量是中药现代化进程中一个具有挑战性且备受关注的话题。深入了解中药生长全过程中的形态、结构、活性成分及动态变化至关重要，这需要高精度的现代技术进行深入阐释。磁共振成像（MRI）是一种融合了核磁共振（NMR）光谱学和成像技术优势的前沿工具。凭借实时、无损及检测能力，MRI此前已被用于在生理过程中监测植物的内部和外部结构以及化合物。在此，对涉及中药整体质量评价的因素进行了研究。鉴于MRI在各种植物中的应用，以几种具有代表性的中药为例，展示了一种通过MRI进行质量可视化的方法，体现了对实时宏观形态、介观结构和微观代谢产物进行无损的整体监测。综上所述，本综述不仅提出了利用MRI进行中药质量可视化的开创性应用模式，也为推进中药质量控制和评价带来了希望。
