de Oliveira Thales Felipe Dos Santos, Gonçalves Michelle Roxo, Martins Marco Antonio Trevizani, Martins Manoela Domingues, Lo Muzio Lorenzo, Visioli Fernanda, Carrard Vinicius Coelho
Department of Oral Medicine, Otorhinolaryngology Service, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil.
Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.
Oral Dis. 2025 Jul;31(7):2179-2190. doi: 10.1111/odi.15247. Epub 2025 Jan 6.
To compare the demographic and clinical profiles of oral lichen planus (OLP) and oral lichenoid lesions (OLL) diagnosed at a reference center in Southern Brazil from 2010 to 2019.
This retrospective study included 117 cases of suspected OLP submitted for biopsy. Investigated variables comprised sociodemographic profiles, medical history, harmful habits, clinical characteristics, and histopathological features. Categorical and numerical variables were analyzed using chi-square and Mann-Whitney tests (p < 0.01), respectively.
Applying strict diagnostic criteria, 29% (n = 34) of cases were classified as OLP and 71% (n = 83) as OLL. OLP cases had mainly multifocal manifestations (82.4%), exhibiting a reticular pattern (100%) and primarily occurring on the buccal mucosa (94.1%). Conversely, OLL cases presented both unilateral (48.2%) and multifocal (51.8%) distributions, with a predominantly atrophic-erosive pattern (77.1%) and higher occurrence on the buccal mucosa (69.9%) and tongue (48.2%). OLL patients reported a higher frequency of systemic disorders and medication use (p < 0.01). Hypertension was the most prevalent condition, leading to the frequent use of cardiovascular medications. Two OLL cases without initial dysplasia underwent malignant transformation.
Patient profiles and clinical manifestations of the entities were similar, highlighting the utility of a differential diagnosis, particularly given the apparent association between malignant transformation and OLL cases.
比较2010年至2019年在巴西南部一家参考中心诊断的口腔扁平苔藓（OLP）和口腔苔藓样病变（OLL）的人口统计学和临床特征。
这项回顾性研究纳入了117例疑似OLP并接受活检的病例。调查变量包括社会人口统计学特征、病史、不良习惯、临床特征和组织病理学特征。分类变量和数值变量分别采用卡方检验和曼-惠特尼检验（p < 0.01）进行分析。
应用严格的诊断标准，29%（n = 34）的病例被分类为OLP，71%（n = 83）为OLL。OLP病例主要表现为多灶性（82.4%），呈现网状图案（100%），主要发生在颊黏膜（94.1%）。相反，OLL病例表现为单侧（48.2%）和多灶性（51.8%）分布，主要为萎缩糜烂型（77.1%），在颊黏膜（69.9%）和舌部（48.2%）发生率更高。OLL患者报告的全身疾病和药物使用频率更高（p < 0.01）。高血压是最常见的疾病，导致心血管药物的频繁使用。2例最初无发育异常的OLL病例发生了恶性转化。
这些疾病的患者特征和临床表现相似，突出了鉴别诊断的实用性，特别是考虑到恶性转化与OLL病例之间明显的关联。
