Glavina Ana, Lugović-Mihić Liborija, Martinović Dinko, Cigić Livia, Biočina-Lukenda Dolores, Šupe-Domić Daniela
Dental Clinic Split, Split, Croatia.
Department of Oral Medicine, Study of Dental Medicine, School of Medicine, University of Split, Split, Croatia.
Oral Dis. 2025 Jul;31(7):2167-2178. doi: 10.1111/odi.15249. Epub 2025 Jan 6.
The aim of our study was to compare the salivary interleukin-6 (IL-6) concentration and the quality of life (QoL) in patients with oral lichen planus (OLP) or burning mouth syndrome (BMS).
A total of 160 subjects participated in the cross-sectional study. The unstimulated whole saliva (UWS) was used as a reference for the determination of salivary IL-6 concentration by enzyme-linked immunosorbent assays (ELISAs). QoL was assessed using the Croatian version of the Oral Health Impact Profile Questionnaire (OHIP-CRO14).
The salivary IL-6 concentration showed no statistically significant difference between patients with OLP, patients with BMS or control subjects (p = 0.244). There was a strong/good positive correlation between symptom intensity (pain/burning) and the OHIP-CRO14 dimension "physical pain" (r = 0.720, p < 0.001) and "physical impossibility" (r = 0.372, p = 0.003) in patients with OLP. There was a good positive correlation between symptom intensity (pain/burning) and the OHIP-CRO14 dimension "handicap" (r = 0.353, p = 0.005) in patients with BMS.
Symptom intensity (pain/burning) showed no correlation with salivary IL-6 concentration in patients with OLP or BMS. A slight increase or decrease in salivary IL-6 concentration in OLP or BMS indicates an inflammatory etiopathogenesis of OLP and a loss of neuroprotection in BMS.
本研究旨在比较口腔扁平苔藓（OLP）或灼口综合征（BMS）患者的唾液白细胞介素-6（IL-6）浓度和生活质量（QoL）。
共有160名受试者参与了这项横断面研究。未刺激的全唾液（UWS）被用作通过酶联免疫吸附测定（ELISA）测定唾液IL-6浓度的参考样本。使用克罗地亚版口腔健康影响概况问卷（OHIP-CRO14）评估生活质量。
OLP患者、BMS患者或对照受试者之间的唾液IL-6浓度无统计学显著差异（p = 0.244）。在OLP患者中，症状强度（疼痛/灼痛）与OHIP-CRO14维度“身体疼痛”（r = 0.720，p < 0.001）和“身体功能受限”（r = 0.372，p = 0.003）之间存在强/良好的正相关。在BMS患者中，症状强度（疼痛/灼痛）与OHIP-CRO14维度“功能障碍”（r = 0.353，p = 0.005）之间存在良好的正相关。
OLP或BMS患者的症状强度（疼痛/灼痛）与唾液IL-6浓度无关。OLP或BMS患者唾液IL-6浓度的轻微升高或降低表明OLP的炎症发病机制以及BMS中神经保护作用的丧失。
