Zhang Lisha, Chu Chao, Zhang Yan, Wang Man
Department of Cardiovascular Medicine, The Second Affiliated Hospital, Xi'an Jiaotong University, Xincheng District, Xi'an, 710004, Shaanxi, People's Republic of China.
Department of Cardiovascular Medicine, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
Acta Diabetol. 2025 Jan 6. doi: 10.1007/s00592-024-02441-8.
To investigate the association of frailty status and its changes with new-onset diabetes.
A total of 4638 participants from the China Health and Retirement Longitudinal Study (CHARLS) were included. Frailty status was assessed by the frailty index (FI) and categorized as robust, pre-frail, and frail. Changes in frailty were assessed based on frailty status at wave1 and wave3 of CHARLS. New-onset diabetes was identified by self-reported physician-diagnosed or diagnosed by glucose or glycosylated haemoglobin during follow-up period. Logistic regression was used to examine the association of frailty and outcomes.
51.6%, 38.1% and 10.3% of the individuals were respectively classified as robust, pre-frail, and frail at baseline. The risk of new-onset diabetes was significantly higher in the pre-frailty [odds ratio (OR) (95% confidence interval (CI)): 1.326 (1.101-1.597), p = 0.003)] and frailty [OR(95% CI): 1.721 (1.304-2.271), p < 0.001)] than the robust. A total of 3145 participants were included in the changes of frailty status analyses. Compared with the stable robust individuals, individuals who developed from robust to frailty status [OR (95%CI): 3.752 (1.647-8.547), p = 0.002] had an elevated risk of new-onset diabetes. In addition, participants who ever had a robust status in the two surveys had a significantly lower risk of new-onset diabetes compared to those who never had a robust status [OR (95%CI) 0.666 (0.483-0.920), p = 0.014)].
Frailty status is significantly associated with the risk of new-onset diabetes. The progression from robust to frailty or pre-frailty increased the risk of new-onset diabetes.
研究虚弱状态及其变化与新发糖尿病之间的关联。
纳入了来自中国健康与养老追踪调查（CHARLS）的4638名参与者。通过虚弱指数（FI）评估虚弱状态，并分为健康、虚弱前期和虚弱。根据CHARLS第1轮和第3轮的虚弱状态评估虚弱的变化。新发糖尿病通过自我报告的医生诊断或在随访期间通过血糖或糖化血红蛋白诊断。采用逻辑回归分析来研究虚弱与结局之间的关联。
在基线时，分别有51.6%、38.1%和10.3%的个体被分类为健康、虚弱前期和虚弱。虚弱前期[比值比（OR）（95%置信区间（CI））：1.326（1.101 - 1.597），p = 0.003]和虚弱[OR（95%CI）：1.721（1.304 - 2.271），p < 0.001]状态下的个体发生新发糖尿病的风险显著高于健康个体。共有3145名参与者纳入了虚弱状态变化分析。与稳定的健康个体相比，从健康状态发展为虚弱状态的个体[OR（95%CI）：3.752（1.647 - 8.547），p = 0.002]发生新发糖尿病的风险升高。此外，在两次调查中曾有过健康状态的参与者与从未有过健康状态的参与者相比，发生新发糖尿病的风险显著更低[OR（95%CI）0.666（0.483 - 0.920），p = 0.014]。
虚弱状态与新发糖尿病风险显著相关。从健康进展为虚弱或虚弱前期会增加新发糖尿病的风险。
