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丹麦一家大型中心引入机器人辅助肾移植:一项试点及可行性研究。

Introducing robot-assisted kidney transplantation in a high-volume centre in Denmark: a pilot and feasibility study.

作者信息

Ortved Milla, Dagnæs-Hansen Julia, Stroomberg Hein V, Karas Vladimir, Rohrsted Malene, Sørensen Søren S, Røder Andreas

机构信息

Urological Research Unit, Department of Urology, Copenhagen University Hospital - Rigshospitalet, Ole Maaloes Vej 24, 2. Floor, 2200, Copenhagen, Denmark.

Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

出版信息

J Robot Surg. 2025 Jan 6;19(1):45. doi: 10.1007/s11701-024-02190-4.

Abstract

Robot-assisted kidney transplantation (RAKT) may reduce surgical complications compared to open kidney transplantation (OKT), but no randomised trials have explored this to date. The aim of the present study is to explore the feasibility of introducing RAKT at our institution, making it available in deceased donor transplantation and evaluate early surgical outcomes prior to performing a randomised trial comparing RAKT to OKT. RAKT was performed at Department of Urology, Copenhagen University Hospital, Rigshospitalet, Denmark. The patients were included from June 2022 until May 2023. The data were collected through the national electronic health records. The data include recipient, donor and intraoperative characteristics, postoperative complications within 90 days graded according to Clavien-Dindo classification and days alive and out of hospital (DAOH). The functional outcomes include eGFR, plasma creatinine, delayed graft function, and rejection episodes. Sixteen RAKTs were performed. Fourteen cases were transplantations with living donors and two cases were with deceased donors. There were no major intra-operative adverse events and no conversions. The median operative time was 223 min and median blood loss 150 ml. The median length of stay was 7 days and median DAOH was 82. Seven complications occurred in five patients at 90 days postoperatively; however, there were no major surgical complications. This study comprehensively assesses patient morbidity following RAKT in a small cohort with results indicating favourable outcomes. This supported our clinical assumption of reduced complications for a randomised trial comparing OKT and RAKT (the ORAKTx trial) which has been initiated (NCT identifier 05730257).

摘要

与开放性肾移植(OKT)相比,机器人辅助肾移植(RAKT)可能会减少手术并发症,但迄今为止尚无随机试验对此进行探索。本研究的目的是探讨在我们机构引入RAKT的可行性,使其可用于尸体供体移植,并在进行比较RAKT与OKT的随机试验之前评估早期手术结果。RAKT在丹麦哥本哈根大学医院里格霍斯皮塔利特泌尿外科进行。患者纳入时间为2022年6月至2023年5月。数据通过国家电子健康记录收集。数据包括受者、供者和术中特征、根据Clavien-Dindo分类分级的90天内术后并发症以及存活出院天数(DAOH)。功能结果包括估算肾小球滤过率(eGFR)、血肌酐、移植肾功能延迟和排斥反应发作次数。共进行了16例RAKT。其中14例为活体供体移植,2例为尸体供体移植。术中无重大不良事件,无中转手术。中位手术时间为223分钟,中位失血量为150毫升。中位住院时间为7天,中位DAOH为82天。术后90天,5例患者出现7例并发症;然而,无重大手术并发症。本研究在一个小队列中全面评估了RAKT术后患者的发病率,并表明结果良好。这支持了我们关于在比较OKT和RAKT的随机试验(ORAKTx试验)中并发症减少的临床假设,该试验已启动(NCT标识符05730257)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4927/11703890/a8ef762286b0/11701_2024_2190_Fig1_HTML.jpg

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