Kolesnikova P S, Pavlova O S, Gulyaev M V, Kuropatkina T A, Pirogov Yu A
Faculty of Physics, Lomonosov Moscow State University, Moscow, Russia.
Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia.
Bull Exp Biol Med. 2024 Dec;178(2):250-254. doi: 10.1007/s10517-025-06316-y. Epub 2025 Jan 6.
Using magnetic resonance imaging (MRI) with radial scanning, images of intact rat lungs and rat lungs with pulmonary hypertension were obtained. The retrospective gating method was applied to construct images of rat lungs during inspiration and expiration phases. Lung volumes at both respiratory phases, relative tidal volume, and the percentage of lung lesions were calculated. Lung volumes at inspiration and expiration were greater by ~4 and ~18%, respectively, and the relative lung tidal volume was lower by ~2.8 times than in intact rats. Constructed fractional ventilation maps showed a ~2.6-fold decrease in ventilation values in the pathological area. Thus, the application of the retrospective gating method allows detecting changes in lung volumes and ventilation, confirming the presence of pathology and its impact on the respiratory function.
使用径向扫描的磁共振成像（MRI）获得了完整大鼠肺和患有肺动脉高压大鼠肺的图像。采用回顾性门控方法构建大鼠肺在吸气和呼气阶段的图像。计算了两个呼吸阶段的肺容积、相对潮气量和肺损伤百分比。吸气和呼气时的肺容积分别增加了约4%和18%，相对肺潮气量比完整大鼠低约2.8倍。构建的分数通气图显示病变区域的通气值下降了约2.6倍。因此，回顾性门控方法的应用能够检测肺容积和通气的变化，证实病理状况的存在及其对呼吸功能的影响。
