Gubin Denis, Boldyreva Julia, Stefani Oliver, Kolomeichuk Sergey, Danilova Liina, Shigabaeva Aislu, Cornelissen Germaine, Weinert Dietmar
Laboratory for Chronobiology and Chronomedicine, Research Institute of Biomedicine and Biomedical Technologies, Medical University, Tyumen, Russia.
Department of Biology, Medical University, Tyumen, Russia.
Chronobiol Int. 2025 Jan;42(1):133-146. doi: 10.1080/07420528.2024.2449015. Epub 2025 Jan 6.
Seven-day actigraphy was performed within 1 month in 122 community-dwelling adults (mean age 24.40 y, 31 (25.4%) men) in the same city of Tyumen, Russia. Groups with different COVID-19 status (present, COVID-19(+), = 79 vs absent, COVID-19(-), = 43) did not differ in mean age, gender distribution, or body mass index. Vaccination status was equally represented in the COVID groups. We found that COVID-19 status, a history of SARS-CoV-2 infection, was differentially associated with daylight susceptibility. Daylight exposure was estimated using parametric and non-parametric indices: 24-h Amplitude, MESOR or M10 of white and blue light exposure (BLE) and compared between the groups. Distinctively in COVID-19(+) individuals, a smaller normalized 24-h amplitude of BLE (NAbl) was associated with lower circadian robustness, assessed by a smaller relative non-parametric amplitude (RA), a lower circadian function index (CFI), later bedtime, later onset of least active 5 h (L5), shorter total sleep duration, later phase and smaller circadian amplitude of physical motor activity. Such associations were absent in the overall COVID-19(-) population or in the vaccinated COVID(-) group. Considering COVID-status and light hygiene, defined as NAbl ≥ 1 versus NAbl < 1, only those with COVID(+) and NAbl < 1 (poorer light hygiene) had a statistically significantly delayed phase of activity and sleep, reduced circadian amplitude of physical activity, and lower circadian robustness. Accounting for gender and BMI, participants diagnosed with COVID-19 at an earlier date were older and had poorer circadian light hygiene. Altogether, our data suggest that those with COVID-19 were more vulnerable to circadian disruption due to poor circadian light hygiene, manifested as phase delay, small amplitude, a less robust circadian pattern of activity, and as delayed sleep. Our data suggest that the need for optimal circadian light hygiene is greater in individuals with a history of SARS-CoV-2 infection.
在俄罗斯秋明市同一城市的122名社区居住成年人（平均年龄24.40岁，31名（25.4%）男性）中，在1个月内进行了为期7天的活动记录仪监测。不同COVID-19状态（存在，COVID-19(+)，=79；不存在，COVID-19(-)，=43）的组在平均年龄、性别分布或体重指数方面没有差异。疫苗接种状态在COVID组中的分布相同。我们发现，SARS-CoV-2感染史即COVID-19状态与日光易感性存在差异关联。使用参数和非参数指标估计日光暴露：24小时振幅、中值（MESOR）或白光和蓝光暴露（BLE）的M10，并在组间进行比较。在COVID-19(+)个体中，独特的是，较小的标准化24小时BLE振幅（NAbl）与较低的昼夜节律稳健性相关，通过较小的相对非参数振幅（RA）、较低的昼夜节律功能指数（CFI）、较晚的就寝时间、最晚活跃5小时（L5）的开始时间、较短的总睡眠时间、较晚的相位和较小的身体运动活动昼夜节律振幅来评估。在整个COVID-19(-)人群或接种疫苗的COVID(-)组中不存在这种关联。考虑到COVID状态和光卫生，定义为NAbl≥1与NAbl<1，只有COVID(+)且NAbl<1（光卫生较差）的个体在活动和睡眠阶段有统计学上显著的延迟、身体活动的昼夜节律振幅降低以及昼夜节律稳健性较低。考虑到性别和BMI，较早诊断出COVID-19的参与者年龄较大且昼夜节律光卫生较差。总之，我们的数据表明，COVID-19患者由于昼夜节律光卫生差更容易受到昼夜节律紊乱的影响，表现为相位延迟、振幅小、活动的昼夜节律模式不稳健以及睡眠延迟。我们的数据表明，有SARS-CoV-2感染史的个体对最佳昼夜节律光卫生的需求更大。
