Pettersson L O, Akerman B
Scand J Plast Reconstr Surg. 1979;13(2):237-40. doi: 10.3109/02844317909013063.
Local anaesthesia by epicutaneous application of the ketocaine solution A2358 gave survival of experimental skin flaps in the guinea pig which corresponded on average to 71% of the total flap. The survival after pentobarbitone anaesthesia, general anaesthesia with ether, and infiltration of prilocaine without and with adrenalin varied between 41 and 53%. The difference in effect between percutaneous anaesthesia with A2358 and the other procedures was statistically significant (p less than 0.001). Epicutaneous application of A2358 followed by one of the other forms of anaesthesia gave a flap survival that did not differ from that following local anaesthesia with A2358 alone, except when followed by injection of prilocaine with adrenalin. The improved survival after epicutaneously applied A2358 is probably attributable to an effect on the peripheral vascular bed resulting in increasing blood supply and nutrition. It may be possible that A2358, for example, could be used in man as a complement to other forms of anaesthesia to provide enhanced tissue survival in skin flaps.
通过表皮涂抹酮卡因溶液A2358进行局部麻醉，可使豚鼠实验性皮瓣存活，平均存活面积占皮瓣总面积的71%。戊巴比妥麻醉、乙醚全身麻醉以及使用和不使用肾上腺素的丙胺卡因浸润麻醉后的皮瓣存活率在41%至53%之间。使用A2358进行经皮麻醉与其他麻醉方法之间的效果差异具有统计学意义（p<0.001）。在表皮涂抹A2358后再采用其他麻醉方式之一，皮瓣存活率与仅使用A2358进行局部麻醉时并无差异，但在随后注射含肾上腺素的丙胺卡因时除外。表皮涂抹A2358后皮瓣存活率提高，可能是由于其对外周血管床产生作用，导致血液供应和营养增加。例如，A2358有可能在人体中作为其他麻醉方式的补充，以提高皮瓣的组织存活率。
