Pontén B, Ohlsén L
Br J Plast Surg. 1977 Oct;30(4):251-4. doi: 10.1016/0007-1226(77)90110-2.
Astra 2337 ketocaine-soaked pads applied to the skin surface produced analgesia adequate for split skin graft cutting 85 out of 86 patients. In 86 per cent, the analgesia was completely satisfactory; a few had some discomfort or pain but all could tolerate this. Application for 1 hour is time enough, but the effect lasts for at least 8 hours and probably longer. Apart from occasional redness and oedema of the skin, no adverse effects wer noted and the blood levels of absorbed ketocaine were far below the toxic level. This simple effective technique is of great value, particularly in such cases as burns who require multiple grafting operations and in whom repeated general anaesthetics can have such adverse effect.
将浸有2337号阿斯特拉（Astra 2337）氯胺酮的垫子敷于皮肤表面，86例患者中有85例产生了足以进行中厚皮片移植切割的镇痛效果。86%的患者镇痛效果完全令人满意；少数患者有一些不适或疼痛，但都能耐受。敷用1小时时间足够，但效果至少持续8小时，可能更长。除皮肤偶尔出现发红和水肿外，未观察到不良反应，吸收的氯胺酮血药浓度远低于中毒水平。这种简单有效的技术具有很大价值，特别是对于需要多次移植手术且反复全身麻醉可能产生不良影响的烧伤患者。
