Pettersson L O
Scand J Plast Reconstr Surg. 1977;11(1):79-82. doi: 10.3109/02844317709025501.
Two different compositions (A2174 and A2337) containing the local anaesthetic ketocaine have been used to bring about percutaneous anaesthesia for the taking of split skin grafts in a total of 50 patients. A2337 was superior to A2174 regarding effect. The necessary time of application using A2337 was determined and found to be approximately one hour. A2337 gave clinically acceptable anaesthesia in all cases (20 patients)- The healing of the skin transplant has been normal. Erythema and oedema at the site of application have been the only unintended effects. The results show that by using A2337, epicutaneous anaesthesia can be a clinically useful alternative to presently used forms of anaesthesia.
两种含有局部麻醉剂酮卡因的不同组合物（A2174和A2337）已被用于为总共50名患者进行取皮移植时实现经皮麻醉。就效果而言，A2337优于A2174。确定了使用A2337的必要应用时间，发现约为一小时。A2337在所有病例（20名患者）中均产生了临床上可接受的麻醉效果——皮肤移植的愈合情况正常。应用部位的红斑和水肿是唯一的意外效果。结果表明，通过使用A2337，表皮麻醉可以成为目前使用的麻醉形式的一种临床上有用的替代方法。
