Tang Qin, Peng Jinzhong, Li Yilu, Liu Lin, Wang Pan, Chen Huafu, Biswal Bharat B
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China.
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China.
Prog Neuropsychopharmacol Biol Psychiatry. 2025 Jan 10;136:111247. doi: 10.1016/j.pnpbp.2025.111247. Epub 2025 Jan 4.
Attention-deficit hyperactivity disorder (ADHD) is a heterogenous behavioral disorder with inattention, hyperactivity and impulsivity symptoms, indicating the important implication of identifying biotypes and its epicenters in understanding disease's pathogenesis. The study investigated the neuromorphic heterogeneity relating to transcriptional similarity architecture in ADHD, and further analyzed the epicenters of network-spreading in each ADHD biotype and their correlations with clinical characteristics. Individuals with ADHD could be identified into two discriminative biotypes that exhibited distinct neuromorphic aberrances. As increased regional cortical thickness deviation in ADHD, the first component of partial least squares (PLS1) positively weighted genes were over-expressed, whereas PLS1 negatively weighted genes were under-expressed as its reduction. Both ADHD biotypes exhibited distinct disease epicenters that distributed in cognitive control and attention networks with significantly heterogeneous characteristics, holding promise for advancing our understanding, and ultimately the treatment, of ADHD. Overall, our findings identified two discriminative biotypes and its epicenters in ADHD, promoting the understanding of underlying transcriptome-neuroimaging relationships.
注意力缺陷多动障碍（ADHD）是一种具有注意力不集中、多动和冲动症状的异质性行为障碍，这表明识别生物型及其中心在理解疾病发病机制方面具有重要意义。该研究调查了与ADHD转录相似性结构相关的神经形态异质性，并进一步分析了每种ADHD生物型中网络传播的中心及其与临床特征的相关性。患有ADHD的个体可被分为两种具有明显差异的生物型，它们表现出不同的神经形态异常。由于ADHD中区域皮质厚度偏差增加，偏最小二乘法（PLS1）的第一个成分中正向加权基因过度表达，而PLS1负向加权基因则随着其减少而表达不足。两种ADHD生物型均表现出分布在认知控制和注意力网络中的明显疾病中心，具有显著的异质性特征，有望促进我们对ADHD的理解并最终推动其治疗。总体而言，我们的研究结果确定了ADHD中的两种具有明显差异的生物型及其中心，促进了对潜在转录组-神经影像学关系的理解。
