Bee Soo-Ling, Hamid Zuratul Ain Abdul
School of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, 14300 Nibong Tebal, Penang, Malaysia.
Int J Biol Macromol. 2025 Mar;295:139504. doi: 10.1016/j.ijbiomac.2025.139504. Epub 2025 Jan 4.
Guided tissue regeneration (GTR) and guided bone regeneration (GBR) are two common dental regenerative procedures used to repair periodontal defects caused by periodontitis. In both procedures, a barrier membrane is placed at the interface between the soft tissue and the periodontal defect, serving to impede the infiltration of soft tissue while creating a secluded space for periodontal regeneration. Recently, barrier membranes based on chitosan (CS) have emerged as a promising avenue for these applications. However, despite numerous studies on the development of CS-based membranes, comprehensive review articles specifically addressing their progress in GTR/GBR applications remain scarce. Herein, we review recent research and advancements in the use of CS-based membranes for periodontal GTR and GBR. The review begins by highlighting the advantageous properties of CS that make it a suitable biomaterial for GTR/GBR applications. Next, the development of composite CS-based membranes, reinforced with various compositions like bioactive fillers and therapeutic agents, is discussed in detail based on recent literature, with a focus on their enhanced efficacy in promoting periodontal regeneration. Finally, the review explores the emergence of functionally graded CS-based membranes, emphasizing their potential to address specific challenges encountered in GTR/GBR procedures.
引导组织再生（GTR）和引导骨再生（GBR）是两种常见的牙科再生手术，用于修复由牙周炎引起的牙周缺损。在这两种手术中，屏障膜放置在软组织和牙周缺损之间的界面处，用于阻止软组织的侵入，同时为牙周再生创造一个隔离空间。最近，基于壳聚糖（CS）的屏障膜已成为这些应用的一个有前景的途径。然而，尽管对基于CS的膜的开发进行了大量研究，但专门论述其在GTR/GBR应用方面进展的综合综述文章仍然很少。在此，我们综述了基于CS的膜在牙周GTR和GBR应用方面的最新研究和进展。综述首先强调了CS的有利特性，使其成为适用于GTR/GBR应用的生物材料。接下来，根据最近的文献详细讨论了用生物活性填料和治疗剂等各种成分增强的复合CS基膜的开发，重点是它们在促进牙周再生方面增强的功效。最后，综述探讨了功能梯度CS基膜的出现，强调了它们应对GTR/GBR手术中遇到的特定挑战的潜力。
