Turusov V S, Parfenov Iu D
Vopr Onkol. 1985;31(2):84-94.
The paper discusses the advantages offered by the statistical evaluation of experimental carcinogenic effect with due regard to mortality from concomitant pathology. The method used complex tables of contingents and analysis was carried out separately in 3 groups of tumors--independent of mortality, fatal and incidental ones. The method was compared with standard procedures which do not take care of the said mortality rate (table of contingents 2 X 2 and precise procedure of Fisher). The data on development of 1,2-dimethylhydrazine-induced tumors of the skin, uterus and ovaries in 5 strains of mice were used in the study.
本文讨论了在适当考虑伴随病理导致的死亡率的情况下，对实验致癌效应进行统计评估所带来的优势。该方法使用了列联表的复杂表格，并分别对3组肿瘤进行分析——与死亡率无关的肿瘤、致命性肿瘤和偶发性肿瘤。该方法与未考虑上述死亡率的标准程序（2×2列联表和费舍尔精确程序）进行了比较。研究中使用了1,2 - 二甲基肼诱导的5种品系小鼠皮肤、子宫和卵巢肿瘤发生的数据。
