Turusov V S, Bazlova L S, Krutovskikh V A
Biull Eksp Biol Med. 1979 May;87(5):458-60.
Subcutaneous injection of 1,2-dimethylhydrazine into female CBA mice once a week resulted in the development of tumours of the colon, anal region, uterus and liver. In 12-13-month-old mice treated with DMH an earlier appearance (week 8) of uterine sarcomas and more rapid increase in the incidence of tumours of the anal region were noted as compared to 3-month-old mice. In pregnant females treated with DMH a statistically significant decrease in the uterine sarcoma incidence was observed (10.3% versus 48.3% in nonpregnant). Pregnancy exerted no effect on the incidence of tumours at other sites. Castration did not affect the time of appearance and the incidence of tumours of any site.
每周一次向雌性CBA小鼠皮下注射1,2 - 二甲基肼会导致结肠、肛门区域、子宫和肝脏出现肿瘤。与3月龄小鼠相比，用二甲基肼处理的12 - 13月龄小鼠子宫肉瘤出现得更早（第8周），肛门区域肿瘤的发病率增加得更快。在用二甲基肼处理的怀孕雌性小鼠中，观察到子宫肉瘤发病率有统计学意义的下降（10.3% 对未怀孕小鼠的48.3%）。怀孕对其他部位肿瘤的发病率没有影响。去势不影响任何部位肿瘤出现的时间和发病率。
