Hassan Omar S, Megahed Magda A, Ghazal Nesma A
Department of Biochemistry, Medical Research Institute, Alexandria University, 165 El-Horreya Avenue, EL-Hadara, POB 21561, Alexandria, Egypt.
Sci Rep. 2025 Jan 6;15(1):1011. doi: 10.1038/s41598-024-82820-x.
Obesity is a rapidly growing epidemic that continues to be a major severe health problem due to its association with various adverse health consequences. Since 1975, the WHO estimates that the prevalence of obesity has tripled globally. Chrysin is a flavone that is mostly found in the Passiflore species of plants and in propolis. The present study was conducted to examine the anti-obesity effect of chrysin on a high-fat diet-induced obesity in rats and to compare their impact to physical activity (swimming). Rats were classified into two groups: the control group and the obese group, which was subdivided into 4 subgroups (8 rats each); an untreated obese group; a chrysin-treated group (oral dose of 100 mg/kg/day); swimming-treated groups (swimming for 1 h/day, five days/week with a constant overload equal to 5% of their weight); and combination-treated groups (chrysin and swimming). After 8 weeks of treatment, blood samples were taken at the end of the experiment for biochemical tests. Animals were then slaughtered to get white adipose tissue (WAT) and skeletal muscle for analysis of the gene expression of the studied genes. In obese rats, therapy with chrysin reduced weight gain, hyperglycaemia, and insulin resistance. Also, the effects of chrysin may be mediated through acting as an anti-inflammatory and antioxidative stress agent. Physical activity (swimming) is a more efficient anti-obesity agent than treating with chrysin alone through upregulation of PPAR-γ and downregulation of Mir-27a. Physical activity with daily supplementation of chrysin showed the best efficiency for the treatment of obesity.
肥胖是一种迅速蔓延的流行病，由于其与各种不良健康后果相关联，仍然是一个主要的严重健康问题。自1975年以来，世界卫生组织估计全球肥胖患病率已增长两倍。白杨素是一种黄酮类化合物，主要存在于西番莲属植物和蜂胶中。本研究旨在检测白杨素对高脂饮食诱导的大鼠肥胖的抗肥胖作用，并将其与体育活动（游泳）的影响进行比较。大鼠分为两组：对照组和肥胖组，肥胖组再细分为4个亚组（每组8只大鼠）；未治疗的肥胖组；白杨素治疗组（口服剂量为100mg/kg/天）；游泳治疗组（每天游泳1小时，每周5天，恒定负荷等于其体重的5%）；联合治疗组（白杨素和游泳）。治疗8周后，在实验结束时采集血样进行生化检测。然后宰杀动物获取白色脂肪组织（WAT）和骨骼肌，用于分析所研究基因的基因表达。在肥胖大鼠中，白杨素治疗可减轻体重增加、高血糖和胰岛素抵抗。此外，白杨素的作用可能通过作为抗炎和抗氧化应激剂来介导。体育活动（游泳）比单独使用白杨素治疗更有效地抗肥胖，通过上调PPAR-γ和下调Mir-27a来实现。每天补充白杨素的体育活动对肥胖治疗显示出最佳效果。
