Sorokin V A, Grigoryeva T V, Kupriyanova O V, Rumyantsev S A, Shestopalov A V
Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
Kazan (Volga region) Federal University, Kazan, Russia.
Bull Exp Biol Med. 2024 Dec;178(2):189-195. doi: 10.1007/s10517-025-06305-1. Epub 2025 Jan 7.
The optimal balance of the intestinal microbiota is considered to be an essential part of the human body that affects many metabolic processes. However, the exact role of the gut microbiota in metabolism is still not fully understood. To investigate the metabolic role of gut microbiota, the content of short-chain fatty acids and tryptophan metabolites was studied in mice with sodium dextran sulfate-induced colitis. It was found that the production of short-chain fatty acids increased on experimental day 14, but by experimental day 60, they completely disappeared. At the same time, indoles of bacterial origin increased on experimental day 60.
肠道微生物群的最佳平衡被认为是人体的一个重要组成部分，它会影响许多代谢过程。然而，肠道微生物群在新陈代谢中的确切作用仍未完全了解。为了研究肠道微生物群的代谢作用，在葡聚糖硫酸钠诱导的结肠炎小鼠中研究了短链脂肪酸和色氨酸代谢物的含量。结果发现，短链脂肪酸的产生在实验第14天增加，但到实验第60天，它们完全消失了。与此同时，细菌来源的吲哚在实验第60天增加。
