Ivanov A N, Kuznetsov A O, Loiko D D, Vlasicheva Yu N, Lengert E V, Ermakov A V
Saratov State Medical University named after V. I. Razumovsky, Saratov, Russia.
Institute of Molecular Theranostics, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Bull Exp Biol Med. 2024 Dec;178(2):209-212. doi: 10.1007/s10517-025-06308-y. Epub 2025 Jan 7.
In vitro and in vivo effects of mesoporous silica nanoparticles (MSN) on the functional activity of platelets were studied in experiments on white rats. MSN particles, neither uncoated nor coated with calcium alginate, induced spontaneous platelet aggregation when added to platelet-rich plasma, but significantly enhanced ADP-induced platelet aggregation. Subcutaneous administration of uncoated and calcium alginate-coated MSN resulted in increased maximum size and rate of platelet aggregate formation 1 day post-injection. In contrast, cellulose-coated MSN had no significant effect on platelet function in vitro or in vivo, suggesting their potential as carriers for targeted drug delivery.
在对白鼠的实验中研究了介孔二氧化硅纳米颗粒（MSN）对血小板功能活性的体外和体内作用。未包被和藻酸钙包被的MSN颗粒添加到富含血小板的血浆中时会诱导血小板自发聚集，但显著增强了ADP诱导的血小板聚集。皮下注射未包被和藻酸钙包被的MSN导致注射后1天血小板聚集体形成的最大尺寸和速率增加。相比之下，纤维素包被的MSN在体外或体内对血小板功能没有显著影响，表明它们作为靶向药物递送载体的潜力。
