Materials Chemistry and Sensors Laboratory - LMSen, State University of Maringá - UEM, 5790 Colombo Avenue, 87020-900, Maringá-PR, Brazil.
Materials Chemistry and Sensors Laboratory - LMSen, State University of Maringá - UEM, 5790 Colombo Avenue, 87020-900, Maringá-PR, Brazil.
Carbohydr Polym. 2018 Sep 15;196:126-134. doi: 10.1016/j.carbpol.2018.04.107. Epub 2018 May 5.
This work reports the preparation, the characterization and the prednisolone release profile of biocompatible hydrogel nanocomposites containing mesoporous silica (SBA) and alginate as a biomaterial for enhanced drug delivery with reduced burst effect and improved mechanical properties. Such systems, which were prepared using specific SBA/alginate-crosslinking chemistry, exhibited interconnecting pore hybrid network owing to both mesoporous silica and hydrogel characteristics. Activated SBA was shown to be a determinant factor in inhibiting initial burst by nearly 90% and the drug was released with minimal burst kinetics. The nanoparticles reduced the movements of polymer chains, affecting macromolecular relaxation, and the distribution of mesoporous silica within the hydrogel made drug release into surrounding liquid less favorable. The proposed systems are biocompatible with human immortalized RWPE-1 prostatic epithelial cells. This report offers an approach of up-to-date interest for the development of advanced biomaterials for further physiological and pathological applications.
本工作报道了含有介孔硅（SBA）和藻酸盐的生物相容性水凝胶纳米复合材料的制备、表征和泼尼松龙释放特性，其作为一种用于增强药物输送的生物材料，具有降低突释效应和改善机械性能的特点。这些系统是使用特定的 SBA/藻酸盐交联化学制备的，由于介孔硅和水凝胶的特性，它们表现出了相互连接的孔混合网络。已证明活化的 SBA 是抑制初始突释的决定因素，将近 90%的药物以最小的突释动力学释放。纳米粒子减少了聚合物链的运动，影响了高分子的松弛，并且介孔硅在水凝胶中的分布使得药物向周围液体中的释放变得不那么有利。所提出的系统与人永生化 RWPE-1 前列腺上皮细胞具有生物相容性。本报告为开发用于进一步生理和病理应用的先进生物材料提供了一种当前感兴趣的方法。
