Genrikhs E E, Shedenkova M O, Voronkov D N, Isaev N K, Stelmashook E V
Research Center of Neurology, Moscow, Russia.
Lomonosov Moscow State University, Moscow, Russia.
Bull Exp Biol Med. 2024 Dec;178(2):196-201. doi: 10.1007/s10517-025-06306-0. Epub 2025 Jan 7.
The number of microglia cells and astrocytes in layer V of the cerebral cortex was estimated on day 7 after damage caused by a unilateral focal traumatic brain injury of the left hemisphere sensorimotor cortex. Quantitative assessment was performed by counting immunocytochemically stained microglia cells (Iba1 marker) and activated astrocytes (GFAP) at different distances from the lesion site. Activation of microglial and astroglial cells was observed not only in the marginal zone of the lesion of the left hemisphere, but also in the intact hemisphere. The data obtained indicate the dissemination of inflammation in focal traumatic brain injury.
在左半球感觉运动皮层单侧局灶性创伤性脑损伤造成损伤后的第7天，对大脑皮层V层中的小胶质细胞和星形胶质细胞数量进行了估计。通过对距损伤部位不同距离处免疫细胞化学染色的小胶质细胞（Iba1标记）和活化星形胶质细胞（GFAP）进行计数来进行定量评估。不仅在左半球损伤的边缘区域观察到了小胶质细胞和星形胶质细胞的活化，在完整的半球中也观察到了。所获得的数据表明局灶性创伤性脑损伤中炎症的扩散。
