Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China; Department of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Int Immunopharmacol. 2022 Jul;108:108754. doi: 10.1016/j.intimp.2022.108754. Epub 2022 Apr 6.
Spinal cord injury (SCI) is a catastrophic event which is still without adequate therapies. Neuroinflammation is the main pathogenesis of secondary damage post-SCI, leading to tissue loss and neurological dysfunction. Previous studies have shown that microglia and astrocytes are the major immune cells in the central nervous system (CNS) and play a crucial role in modulating neuroinflammatory responses. In this study, we mainly review the effects of neuroinflammation in SCI, focusing on the contributions of microglia and astrocytes and their cross-talk. Furthermore, we will also discuss therapeutic strategies on how to regulate their immunophenotype to suppress robust inflammation and facilitate injury prognosis.
脊髓损伤（SCI）是一种灾难性事件，目前仍缺乏有效的治疗方法。神经炎症是 SCI 后继发性损伤的主要发病机制，导致组织损失和神经功能障碍。先前的研究表明，小胶质细胞和星形胶质细胞是中枢神经系统（CNS）中的主要免疫细胞，在调节神经炎症反应中起着至关重要的作用。在本研究中，我们主要综述了神经炎症在 SCI 中的作用，重点讨论了小胶质细胞和星形胶质细胞的作用及其相互作用。此外，我们还将讨论如何调节它们的免疫表型以抑制强烈的炎症反应并促进损伤预后的治疗策略。
