Zhou Lei, Zhang Lineng, Xu Feng
Department of Otolaryngology-Head and Neck Surgery, Zhongshan Hospital, Fudan University, Fenglin Road 180, Shanghai, 200032, China.
Department of Biotechnology and Biomedical Laboratory Sciences, Shanghai University of Medicine & Health Sciences Medical Technology College, Zhouzhu Road 279, Shanghai, 201318, China.
BMC Infect Dis. 2025 Jan 6;25(1):29. doi: 10.1186/s12879-024-10364-6.
To identify specific clinical signs of Omicron pharyngitis infection.
A clinical cross-sectional retrospective study was designed to analyze the primary symptoms of pharyngitis in outpatients seeking treatment for sore throat. Pharyngeal congestion, mucosal edema, were measured using a visual analogue assessment score (0-10) while the presence of ulcers, no-tonsil-swelling, no-tonsil-exudate. They were recorded as "yes" or "no "as two-Categorical data by two senior clinicians, respectively. Significant clinical signs were selected and combined to form a diagnostic panel using SPSS software to differentiate between Omicron pharyngitis and other sore throat cases. The efficiency of the panel was calculated.
A total of 39 sore throat patients were included in the study, including 15 confirmed cases of Omicron pharyngitis through nuclear acid or Sars-Cov-2 virus antigen testing, and 24 cases of common pharyngitis caused by other pathogens. Mucosal congestion and edema were identified as the most significant symptoms and consolidated into a single working group. When combined with the third significant symptom of no-tonsil-swelling, the three-sign-combined diagnostic panel was found to have a high diagnostic efficiency. Mucosal congestion and edema were the most significant signs. When mucosal congestion and edema were consolidated into a single working panel, the cut-off values were determined to be 7.5 and 1, respectively. When combined with the third significant symptom no-tonsil-swelling, the three-sign diagnostic panel was found to have a high diagnostic efficiency. When compared with the gold standard measurement of Sars-Cov-2 virus antigen or nucleic acid, the diagnostic panel has a sensitivity of 66.7% and a specificity of 91.7%.
A combination of three signs may be a useful diagnostic tool for Omicron pharyngitis. Clinical signs of dramatic mucosal congestion and edema, non-swollen tonsils are the characteristics of Omicron pharyngitis.
确定奥密克戎咽炎感染的特定临床体征。
设计一项临床横断面回顾性研究，以分析因咽痛就诊的门诊患者咽炎的主要症状。使用视觉模拟评估评分（0 - 10）测量咽部充血、黏膜水肿情况，同时观察溃疡、扁桃体无肿大、扁桃体无渗出物的情况。由两名资深临床医生分别将其记录为“是”或“否”作为二分类数据。选择并合并显著的临床体征，使用SPSS软件形成诊断组，以区分奥密克戎咽炎和其他咽痛病例。计算该诊断组的效能。
本研究共纳入39例咽痛患者，其中15例经核酸或新冠病毒抗原检测确诊为奥密克戎咽炎，24例为其他病原体引起的普通咽炎。黏膜充血和水肿被确定为最显著的症状，并合并为一个工作组。当与第三个显著症状扁桃体无肿大相结合时，发现三体征联合诊断组具有较高的诊断效能。黏膜充血和水肿是最显著的体征。当将黏膜充血和水肿合并为一个工作诊断组时，确定的截断值分别为7.5和1。当与第三个显著症状扁桃体无肿大相结合时，发现三体征诊断组具有较高的诊断效能。与新冠病毒抗原或核酸的金标准检测相比，该诊断组的敏感性为66.7%，特异性为91.7%。
三种体征的组合可能是诊断奥密克戎咽炎的有用工具。黏膜显著充血和水肿、扁桃体无肿大是奥密克戎咽炎的临床特征。
