Marlina Dina, Utomo Aditya, Adriansyah Putri Nadhira Adinda, Pelitawati Dewi Rani, Poernomo Megawati Al'badly Ponco Dewi, Sumawan Herman, Handono Budi, Aziz Muhammad Alamsyah
Department of Obstetrics and Gynecology, Padjadjaran University, Bandung, West Java, Indonesia.
Faculty of Medicine, Padjadjaran University, Bandung, West Java, Indonesia.
Med Sci Monit. 2025 Jan 7;31:e946167. doi: 10.12659/MSM.946167.
BACKGROUND Urinary tract infections (UTIs) are common during pregnancy and can negatively impact maternal and neonatal health. Hypertension in pregnancy is a leading cause of maternal morbidity. UTIs can contribute to hypertension development through mechanisms like inflammation, leading to endothelial dysfunction and impaired placental development. This study aimed to evaluate the association between bacteriuria and hypertension in pregnant women. MATERIAL AND METHODS This multicenter study was conducted at 2 hospitals in Indonesia from 2022 to 2023, including 742 pregnant women who met the inclusion criteria. The women were grouped based on bacteriuria and hypertension status. The bacteriuria-positive group had 322 women, of which 125 had hypertension. The bacteriuria-negative group included 421 women, with 101 having hypertension. Statistical analysis was performed to determine the odds ratio (OR) and prevalence ratio. RESULTS Women with bacteriuria were twice as likely to develop hypertension compared to those without (OR=2.01, 95% CI: 1.47-2.76, P<0.001). In the hypertensive group, 55.3% had bacteriuria compared to 38.1% in the normotensive group. Conversely, women without bacteriuria had a reduced likelihood of developing hypertension (OR=0.5, 95% CI: 0.38-1.02, P<0.001). CONCLUSIONS This study highlights a significant association between bacteriuria and increased hypertension risk in pregnancy. Given that bacteriuria is routinely screened for, it can be a valuable tool for identifying women at higher risk of hypertensive disorders. Monitoring bacteriuria-positive women is recommended to help manage and potentially prevent hypertensive complications during pregnancy.
尿路感染（UTIs）在孕期很常见，会对母婴健康产生负面影响。妊娠期高血压是孕产妇发病的主要原因。尿路感染可通过炎症等机制导致高血压的发生，进而引起内皮功能障碍和胎盘发育受损。本研究旨在评估孕妇菌尿与高血压之间的关联。
本多中心研究于2022年至2023年在印度尼西亚的2家医院进行，纳入了742名符合纳入标准的孕妇。这些女性根据菌尿和高血压状况进行分组。菌尿阳性组有322名女性，其中125名患有高血压。菌尿阴性组包括421名女性，其中101名患有高血压。进行统计分析以确定比值比（OR）和患病率比。
与无菌尿的女性相比，有菌尿的女性患高血压的可能性是其两倍（OR = 2.01，95% CI：1.47 - 2.76，P < 0.001）。在高血压组中，55.3%的女性有菌尿，而血压正常组这一比例为38.1%。相反，无菌尿的女性患高血压的可能性降低（OR = 0.5，95% CI：0.38 - 1.02，P < 0.001）。
本研究强调了菌尿与孕期高血压风险增加之间的显著关联。鉴于菌尿是常规筛查项目，它可以成为识别高血压疾病高危女性的有价值工具。建议对菌尿阳性的女性进行监测，以帮助管理并潜在预防孕期高血压并发症。
