孕期尿路感染与子痫前期之间的关联：一项荟萃分析。
The association between urinary tract infection during pregnancy and preeclampsia: A meta-analysis.
作者信息
Yan Ling, Jin Yu, Hang Hongdong, Yan Bin
机构信息
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen Department of Obstetrics and Gynecology, No. 210 Hospital of PLA Department of Nephrology, The First Affiliated Hospital of Dalian Medical University Department of Obstetrics and Gynecology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
出版信息
Medicine (Baltimore). 2018 Sep;97(36):e12192. doi: 10.1097/MD.0000000000012192.
OBJECTIVE
The association between urinary tract infection (UTI) during pregnancy and preeclampsia (PE) continues to be the subject of debate. This meta-analysis aimed to examine the relationship between UTI during pregnancy and PE.
STUDY DESIGN
Observational studies up to October 2017, extracted from Medline, PubMed, Cochrane Library, and Embase databases, were included in the analysis. Data were extracted to 4-fold table, and the pooled odds ratio (OR) and 95% confidence intervals (CIs) of respective studies were calculated. Then meta-analysis was performed.
RESULTS
Nineteen studies qualified the inclusion criteria. Urinary tract infection during pregnancy was found to be a risk factor for the development of PE (OR: 1.31, 95% CI: 1.22-1.40).
CONCLUSION
Occurrence of UTI during pregnancy increases the risk of PE in pregnant women. Screening for, and treatment of UTI should be part of routine antenatal care, especially in developing countries.
目的
孕期尿路感染（UTI）与先兆子痫（PE）之间的关联仍是一个有争议的话题。本荟萃分析旨在研究孕期UTI与PE之间的关系。
研究设计
分析纳入了截至2017年10月从Medline、PubMed、Cochrane图书馆和Embase数据库中提取的观察性研究。数据被提取到四格表中，并计算各研究的合并比值比（OR）和95%置信区间（CI）。然后进行荟萃分析。
结果
19项研究符合纳入标准。发现孕期UTI是PE发生的一个危险因素（OR：1.31，95%CI：1.22-1.40）。
结论
孕期UTI的发生会增加孕妇患PE的风险。UTI的筛查和治疗应成为常规产前护理的一部分，尤其是在发展中国家。
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