Hüttel M S, Bang U
Acta Anaesthesiol Scand. 1985 Feb;29(2):209-11. doi: 10.1111/j.1399-6576.1985.tb02187.x.
The clinical effects of a standard 2 mg flunitrazepam tablet given sublingually for premedication were evaluated in a group of 50 patients undergoing otorhinolaryngologic surgery. A comparable group of 49 patients received 10 mg of diazepam orally. The degree of sedation and anxiety was assessed objectively and subjectively before induction of anaesthesia. Flunitrazepam produced better sedation judged by the observer as well as by the patients. There was less anxiety in the flunitrazepam group but this was not statistically significant. Side effects were few and patient acceptability high. Sublingual premedication using flunitrazepam could be a useful alternative to other forms of premedication.
对一组50例接受耳鼻喉科手术的患者评估了舌下含服2mg标准氟硝西泮片剂用于术前用药的临床效果。另一组49例可比患者口服10mg地西泮。在麻醉诱导前对镇静程度和焦虑程度进行了客观和主观评估。观察者和患者均判断氟硝西泮产生了更好的镇静效果。氟硝西泮组的焦虑较少，但无统计学意义。副作用少，患者接受度高。舌下含服氟硝西泮进行术前用药可能是其他术前用药形式的一种有用替代方法。
