Department of Nutrition and Food Hygiene, School of Public Health, Guangzhou Medical University, Guangzhou 511436, China.
Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China.
Nutrients. 2024 May 15;16(10):1492. doi: 10.3390/nu16101492.
Serum vitamin D is associated with hyperuricemia. However, previous studies have been controversial, with limited focus on children and adolescents.
This study aimed to examine the cross-sectional and longitudinal associations between serum vitamin D and serum uric acid (SUA) levels in children and adolescents.
The cross-sectional survey comprised 4777 participants aged 6 to 18 years, while the longitudinal survey involved 1641 participants aged 6 to 12 years, all derived from an ongoing cohort study in Shenzhen, China. Restricted cubic splines were used to visualize the dose-response relationship between vitamin D and SUA and the risk of higher SUA status. Two-segment generalized linear models (GLM) and logistic models were used to assess the association between vitamin D and SUA and higher SUA status, respectively. The longitudinal analysis used GLM.
We observed an inverted U-shaped relationship between vitamin D and SUA (-overall < 0.0001, -nonlinear = 0.0002), as well as the risk of higher SUA status (-overall = 0.0054, -nonlinear = 0.0015), with the vitamin D inflection point at 24.31 and 21.29 ng/mL, respectively. A 10 ng/mL increment in 25(OH)D levels, when below 20.92 ng/mL, was associated with a 68% rise in the risk of higher SUA status (OR: 1.68, 95%CI: 1.07-2.66). Conversely, when 25(OH)D levels were above or equal to 20.92 ng/mL, a 10 ng/mL increment was associated with a 45% reduction risk of higher SUA status (OR: 0.55, 95%CI: 0.36-0.84). Longitudinal analysis indicated that the annual change of SUA was from -4.80 (β, 95%CI: -10.74, 1.13) to -9.00 (β, 95%CI: -15.03, -2.99) and then to -6.77 (β, 95%CI: -12.83, -0.71, for trend = 0.0212) μmol/L when increasing the quartile of vitamin D.
An inverse U-shaped relationship was observed between vitamin D and SUA as well as the risk of higher SUA status. Sufficient vitamin D levels appear to play a preventative role against the age-related increase in SUA. Ensuring adequate vitamin D levels may be beneficial in improving uric acid metabolism.
血清维生素 D 与高尿酸血症有关。然而，之前的研究存在争议，且研究对象主要集中在儿童和青少年。
本研究旨在探讨儿童和青少年血清维生素 D 与血清尿酸（SUA）水平的横断面和纵向关联。
横断面调查包括 4777 名年龄在 6 至 18 岁的参与者，纵向调查包括 1641 名年龄在 6 至 12 岁的参与者，所有参与者均来自中国深圳的一项正在进行的队列研究。限制性立方样条用于可视化维生素 D 和 SUA 之间的剂量-反应关系以及更高 SUA 状态的风险。使用双段广义线性模型（GLM）和逻辑模型分别评估维生素 D 与 SUA 和更高 SUA 状态之间的关联。纵向分析使用 GLM。
我们观察到维生素 D 和 SUA 之间呈倒 U 型关系（总体<0.0001，非线性=-0.0002），以及更高 SUA 状态的风险（总体=0.0054，非线性=0.0015），维生素 D 的拐点分别为 24.31 和 21.29ng/mL。当 25（OH）D 水平低于 20.92ng/mL 时，每增加 10ng/mL，SUA 水平升高的风险增加 68%（OR：1.68，95%CI：1.07-2.66）。相反，当 25（OH）D 水平高于或等于 20.92ng/mL 时，每增加 10ng/mL，SUA 水平升高的风险降低 45%（OR：0.55，95%CI：0.36-0.84）。纵向分析表明，SUA 的年变化从-4.80（β，95%CI：-10.74，1.13）变为-9.00（β，95%CI：-15.03，-2.99），然后变为-6.77（β，95%CI：-12.83，-0.71，趋势=0.0212）μmol/L，当维生素 D 的四分位间距增加时。
观察到维生素 D 与 SUA 以及更高 SUA 状态的风险之间呈倒 U 型关系。充足的维生素 D 水平似乎对与年龄相关的 SUA 升高具有预防作用。确保足够的维生素 D 水平可能有助于改善尿酸代谢。
