Identifying the factors affecting quality of life among brucellosis patients in Herat, Afghanistan: a case-control study.

Brucellosis remains a significant public health concern, especially in regions like the Mediterranean and Afghanistan. While its direct health effects are well-documented, its impact on quality of life is less explored. This study investigated the risk factors and quality of life effects of brucellosis in Herat, Afghanistan. Between October 2020 and February 2021, 155 participants were enrolled at Herat Regional Hospital and affiliated brucellosis laboratories. The sample included 75 individuals with confirmed brucellosis and 80 controls without a history of the disease. Data were collected using structured questionnaires, and quality of life was assessed with the SF-36. Statistical analyses included chi-square tests, logistic regression, and General Linear Model. Key risk factors associated with brucellosis included marriage, lower education, contact with pets, infected family members, and using non-protected water (p < 0.05). Logistic regression confirmed increased odds of infection linked to these exposures. Quality of life assessments revealed significantly lower SF-36 scores among male patients across most components, with similar trends observed in female patients. Brucellosis significantly impacts quality of life, particularly among men, and is strongly linked to specific risk factors. Public health measures are essential to reduce infection rates and improve well-being in this region.