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五价疫苗诱导的免疫性血小板减少症:来自尼泊尔的一例报告。

Pentavalent Vaccine-Induced Immune Thrombocytopenia: A Case Report From Nepal.

作者信息

Khadayat Ramesh, Shrestha Sailesh, Gautam Tilak, Magar Sagar Rana, Bhatta Prashant

机构信息

Patan Hospital Patan Academy of Health Science Lalitpur Nepal.

出版信息

Clin Case Rep. 2025 Jan 6;13(1):e70064. doi: 10.1002/ccr3.70064. eCollection 2025 Jan.

Abstract

Immune thrombocytopenia (ITP) is an autoimmune disorder marked by a low platelet count, leading to symptoms ranging from mild to severe bleeding. It can be triggered by various factors, including idiopathic origins, medications, malignancies, infections, and other autoimmune conditions. Though rare, ITP can also occur postvaccination. We report a case of a 3-month-old male who developed petechial rashes and mucosal bleeding following Pentavalent vaccination. This highlights the need for clinicians to recognize ITP as a potential complication of the Pentavalent vaccine. Educating parents about this rare but serious side effect is crucial.

摘要

免疫性血小板减少症(ITP)是一种自身免疫性疾病,其特征为血小板计数低,可导致从轻度到重度出血的各种症状。它可由多种因素引发,包括特发性病因、药物、恶性肿瘤、感染及其他自身免疫性疾病。虽然罕见,但ITP也可在接种疫苗后发生。我们报告一例3个月大男性,在接种五价疫苗后出现瘀点皮疹和黏膜出血。这凸显了临床医生将ITP识别为五价疫苗潜在并发症的必要性。对家长进行关于这种罕见但严重副作用的教育至关重要。

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Vaccine-associated thrombocytopenia.疫苗相关血小板减少症。
Thromb Res. 2022 Dec;220:12-20. doi: 10.1016/j.thromres.2022.09.017. Epub 2022 Sep 26.
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Immune Thrombocytopenia in Children: Consensus and Controversies.儿童免疫性血小板减少症:共识与争议。
Indian J Pediatr. 2020 Feb;87(2):150-157. doi: 10.1007/s12098-019-03155-4. Epub 2020 Jan 11.
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Pediatric ITP: is it different from adult ITP?儿童 ITP:与成人 ITP 有何不同?
Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):405-411. doi: 10.1182/asheducation-2018.1.405.

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