肠道微生物群能解释有症状的非复杂性憩室病患者急性憩室炎的发生吗？
Can gut microbiota explain acute diverticulitis occurrence in patients with symptomatic uncomplicated diverticular disease?
作者信息
Tursi Antonio, Procaccianti Giorgia, D'Amico Federica, DE Bastiani Rudi, Turroni Silvia
机构信息
Territorial Gastroenterology Service, Barletta-Andria-Trani Local Health Agency, 49 Via Torino, Andria 76123, Italy.
Department of Medical and Surgical Sciences, School of Medicine, Catholic University, Rome, Italy.
出版信息
Biosci Microbiota Food Health. 2025;44(1):1-3. doi: 10.12938/bmfh.2024-068. Epub 2024 Sep 5.
Why patients with symptomatic uncomplicated diverticular disease (SUDD) may develop acute diverticulitis (AD) is still unknown. We analyzed the gut microbiota (GM) in two SUDD patients, one who did experience SUDD recurrence but not AD occurrence (case 1) and one who did experience AD occurrence during follow-up (case 2). The GM of these patients showed differences in terms of phyla (Firmicutes and Bacteroidota in case 1; Actinobacteriota and Proteobacteria in case 2) and subgenera ( and in case 1 and , , , , group, and in case 2). This novel insight may advance our ecological understanding of this complex disease.
有症状的非复杂性憩室病（SUDD）患者为何会发展为急性憩室炎（AD）仍不清楚。我们分析了两名SUDD患者的肠道微生物群（GM），一名经历了SUDD复发但未发生AD（病例1），另一名在随访期间发生了AD（病例2）。这些患者的肠道微生物群在门水平（病例1中的厚壁菌门和拟杆菌门；病例2中的放线菌门和变形菌门）和亚属水平（病例1中的 和 ；病例2中的 、 、 、 组和 ）存在差异。这一新见解可能会推进我们对这种复杂疾病的生态学理解。
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