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Pre-oxygenation using high flow humidified nasal oxygen or face mask oxygen in pregnant people - a prospective randomised controlled crossover non-inferiority study (The HINOP2 study).对孕妇使用高流量湿化鼻导管吸氧或面罩吸氧进行预氧合 - 一项前瞻性随机对照交叉非劣效性研究(HINOP2 研究)。
Int J Obstet Anesth. 2024 Nov;60:104236. doi: 10.1016/j.ijoa.2024.104236. Epub 2024 Jul 23.
2
Real-world evidence for the utility of serum soluble fms-like tyrosine kinase 1/placental growth factor test for routine clinical evaluation of hospitalized women with hypertensive disorders of pregnancy.血清可溶性fms样酪氨酸激酶1/胎盘生长因子检测在妊娠高血压疾病住院女性常规临床评估中的应用的真实世界证据。
Am J Obstet Gynecol. 2025 Apr;232(4):385.e1-385.e21. doi: 10.1016/j.ajog.2024.07.015. Epub 2024 Jul 17.
3
First Trimester Placental Biomarkers for Pregnancy Outcomes.早孕期胎盘生物标志物与妊娠结局。
Int J Mol Sci. 2024 Jun 2;25(11):6136. doi: 10.3390/ijms25116136.
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Racial Disparity in Severe Maternal Morbidity Associated with Hypertensive Disorders in Washington State: A Retrospective Cohort Study.种族差异与华盛顿州高血压疾病相关的严重产妇发病率:一项回顾性队列研究。
Matern Child Health J. 2024 Jul;28(7):1234-1241. doi: 10.1007/s10995-024-03920-8. Epub 2024 Feb 26.
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Circulating Angiogenic Factor Levels in Hypertensive Disorders of Pregnancy.妊娠期高血压疾病相关循环血管生成因子水平。
NEJM Evid. 2022 Dec;1(12):EVIDoa2200161. doi: 10.1056/EVIDoa2200161. Epub 2022 Nov 9.
6
Preeclampsia Prediction Using Machine Learning and Polygenic Risk Scores From Clinical and Genetic Risk Factors in Early and Late Pregnancies.利用机器学习和来自早孕期和晚孕期临床及遗传危险因素的多基因风险评分预测子痫前期。
Hypertension. 2024 Feb;81(2):264-272. doi: 10.1161/HYPERTENSIONAHA.123.21053. Epub 2023 Oct 30.
7
Recent Advances in the Prevention and Screening of Preeclampsia.子痫前期预防与筛查的最新进展
J Clin Med. 2023 Sep 17;12(18):6020. doi: 10.3390/jcm12186020.
8
From Biomarkers to the Molecular Mechanism of Preeclampsia-A Comprehensive Literature Review.从生物标志物到子痫前期的分子机制——全面文献综述。
Int J Mol Sci. 2023 Aug 26;24(17):13252. doi: 10.3390/ijms241713252.
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Postpartum Home Blood Pressure Monitoring: A Systematic Review.产后家庭血压监测:系统评价。
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Polygenic prediction of preeclampsia and gestational hypertension.多基因预测子痫前期和妊娠期高血压。
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子痫前期和子痫:加强检测与治疗以降低发病率。

Preeclampsia and eclampsia: Enhanced detection and treatment for morbidity reduction.

作者信息

Kovacheva Vesela P, Venkatachalam Shakthi, Pfister Claire, Anwer Tooba

机构信息

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, L1, Boston, MA, 02115, USA.

UCT Department of Anaesthesia and Perioperative Medicine, Groote Schuur Hospital, Main Road, Observatory, Cape Town, Postal code 7935, South Africa.

出版信息

Best Pract Res Clin Anaesthesiol. 2024 Sep;38(3):246-256. doi: 10.1016/j.bpa.2024.11.001. Epub 2024 Nov 19.

DOI:10.1016/j.bpa.2024.11.001
PMID:39764814
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11707392/
Abstract

Preeclampsia is a life-threatening complication that develops in 2-8% of pregnancies. It is characterized by elevated blood pressure after 20 weeks of gestation and may progress to multiorgan dysfunction, leading to severe maternal and fetal morbidity and mortality. The only definitive treatment is delivery, and efforts are focused on early risk prediction, surveillance, and severity mitigation. Anesthesiologists, as part of the interdisciplinary team, should evaluate patients early in labor in order to optimize cardiovascular, pulmonary, and coagulation status. Neuraxial techniques are safe in the absence of coagulopathy and aid avoidance of general anesthesia, which is associated with high risk in these patients. This review aims to provide anaesthesiologists with a comprehensive update on the latest strategies and evidence-based practices for managing preeclampsia, with an emphasis on perioperative care.

摘要

子痫前期是一种危及生命的并发症,在2%至8%的妊娠中发生。其特征是妊娠20周后血压升高,并可能进展为多器官功能障碍,导致严重的母婴发病和死亡。唯一确定的治疗方法是分娩,工作重点是早期风险预测、监测和减轻严重程度。作为跨学科团队的一员,麻醉医生应在分娩早期对患者进行评估,以优化心血管、肺部和凝血状态。在没有凝血病的情况下,神经轴技术是安全的,有助于避免全身麻醉,全身麻醉在这些患者中具有高风险。本综述旨在为麻醉医生提供关于管理子痫前期的最新策略和循证实践的全面更新,重点是围手术期护理。